WormFlux: mechanistic analysis of C. elegans metabolism

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Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	gthrd
Name .....................................................	:	Reduced glutathione, etc.Glutathione, 5-L-Glutamyl-L-cysteinylglycine, N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine, gamma-L-Glutamyl-L-cysteinyl-glycine, GSH
Model ID .....................................................	:	C00051
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00051
Formula .....................................................	:	C10H16N3O6S
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	gthrd
Other associations .....................................................	:	See reaction table below (17 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Go to map

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC07034Name: Glutathione: 5-HPETE oxidoreductase Type: Regular Location: Cytosol KEGG ID: R07034 click to see details on this item	1.11.1.9Name: glutathione peroxidase Other names: GSH peroxidase, selenium-glutathione peroxidase, reduced glutathione peroxidase click to see details on this item	[c] : (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + 5HPETName: "5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate" Formula: C20H31O4 Charge: -1 click to see details on this item		gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + 5HETEName: 5-Hydroxyeicosatetraenoate Formula: C20H31O3 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	gpx-1 \| gpx-2 \| gpx-3 \| gpx-4 \| gpx-5 \| gpx-7 \| gpx-8	Arachidonic acid metabolism
RC00494Name: glutathione gamma-glutamylaminopeptidase Type: Regular Location: Cytosol KEGG ID: R00494 click to see details on this item	3.4.19.13Name: glutathione hydrolase Other names: glutathionase, GGT (ambiguous), gamma-glutamyltranspeptidase (ambiguous) click to see details on this item	[c] : gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		cglyName: Cys-Gly Formula: C5H10N2O3S Charge: 0 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	C53D5.5 \| H14N18.4 \| T03D8.6 \| T19H12.6 \| Y7A9A.1 \| Y97E10AR.2	Glutathione metabolism
RC01262Name: glutathione:L-amino-acid 5-glutamyltransferase Type: Regular Location: Cytosol KEGG ID: R01262 click to see details on this item	2.3.2.2Name: gamma-glutamyltransferase Other names: glutamyl transpeptidase, alpha-glutamyl transpeptidase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transpeptidase (ambiguous), gamma-GPT, gamma-GT, gamma-GTP, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase, GGT (ambiguous), gamma-glutamyltranspeptidase (ambiguous) click to see details on this item	[c] : ala-LName: L-Alanine Formula: C3H7NO2 Charge: 0 click to see details on this item + gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item		cglyName: Cys-Gly Formula: C5H10N2O3S Charge: 0 click to see details on this item + glualaName: 5-L-Glutamyl-L-alanine Formula: C8H13N2O5 Charge: -1 click to see details on this item	C53D5.5 \| H14N18.4 \| T03D8.6 \| T19H12.6 \| Y7A9A.1 \| Y97E10AR.2	Glutathione metabolism
RC00497Name: gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming) Type: Regular Location: Cytosol KEGG ID: R00497 click to see details on this item	6.3.2.3Name: glutathione synthase Other names: glutathione synthetase, GSH synthetase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + glucysName: gamma-L-Glutamyl-L-cysteine Formula: C8H13N2O5S Charge: -1 click to see details on this item + glyName: Glycine Formula: C2H5NO2 Charge: 0 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	gss-1	Cysteine metabolism
RC00115Name: glutathione:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00115 click to see details on this item	1.8.1.7Name: glutathione-disulfide reductase Other names: glutathione reductase, glutathione reductase (NADPH), NADPH-glutathione reductase, GSH reductase, GSSG reductase, NADPH-GSSG reductase, glutathione S-reductase, NADPH:oxidized-glutathione oxidoreductase click to see details on this item	[c] : gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	gsr-1	Glutathione metabolism
RC00274Name: glutathione:hydrogen-peroxide oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00274 click to see details on this item	1.11.1.9Name: glutathione peroxidase Other names: GSH peroxidase, selenium-glutathione peroxidase, reduced glutathione peroxidase click to see details on this item	[c] : (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item		gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	gpx-1 \| gpx-2 \| gpx-3 \| gpx-4 \| gpx-5 \| gpx-7 \| gpx-8	Glutathione metabolism
RM00115Name: glutathione:NADP+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00115 click to see details on this item	1.8.1.7Name: glutathione-disulfide reductase Other names: glutathione reductase, glutathione reductase (NADPH), NADPH-glutathione reductase, GSH reductase, GSSG reductase, NADPH-GSSG reductase, glutathione S-reductase, NADPH:oxidized-glutathione oxidoreductase click to see details on this item	[m] : gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	trxr-2	Glutathione metabolism
RC01108Name: glutathione dehydrogenase (ascorbate) Type: Regular Location: Cytosol KEGG ID: R01108 click to see details on this item	1.8.5.1Name: glutathione dehydrogenase (ascorbate) Other names: dehydroascorbic reductase, dehydroascorbic acid reductase, glutathione dehydroascorbate reductase, DHA reductase , dehydroascorbate reductase, GDOR, glutathione:dehydroascorbic acid oxidoreductase click to see details on this item	[c] : dhdascbName: Dehydroascorbate Formula: C6H6O6 Charge: 0 click to see details on this item + (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item		ascb-LName: L-Ascorbate Formula: C6H8O6 Charge: 0 click to see details on this item + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item	Unknown	Glutathione metabolism
RC03956Name: Glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase Type: Regular Location: Cytosol KEGG ID: R03956 click to see details on this item	2.3.2.15Name: glutathione gamma-glutamylcysteinyltransferase Other names: phytochelatin synthase, gamma-glutamylcysteine dipeptidyl transpeptidase click to see details on this item	[c] : gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item		pchltnName: Phytochelatin Formula: C2H5NO2(C8H11N2O4S)n Charge: -1 click to see details on this item + glyName: Glycine Formula: C2H5NO2 Charge: 0 click to see details on this item	pcs-1	Glycine and threonine metabolism
RC00527Name: S-Formylglutathione hydrolase Type: Regular Location: Cytosol KEGG ID: R00527 click to see details on this item	3.1.2.12Name: S-formylglutathione hydrolase click to see details on this item	[c] : SfglutthName: S-Formylglutathione Formula: C11H16N3O7S Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		forName: Formate Formula: CH1O2 Charge: -1 click to see details on this item + gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Y48G10A.1	Miscellaneous
RC06982Name: formaldehyde glutathione ligase (spontaneous) Type: Regular Location: Cytosol KEGG ID: R06982 click to see details on this item	spontaneous	[c] : faldName: Formaldehyde Formula: CH2O Charge: 0 click to see details on this item + gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item		hmgthName: hydroxymethylglutathione Formula: C11H18N3O7S Charge: -1 click to see details on this item	Not applicable	Miscellaneous
RM01736Name: (R)-S-Lactoylglutathione hydrolase Type: Regular Location: Mitochondria KEGG ID: R01736 click to see details on this item	3.1.2.6Name: hydroxyacylglutathione hydrolase Other names: glyoxalase II, S-2-hydroxylacylglutathione hydrolase, hydroxyacylglutathione hydrolase, acetoacetylglutathione hydrolase click to see details on this item	[m] : lgt-SName: (R)-S-Lactoylglutathione Formula: C13H20N3O8S Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Y17G7B.3	Methylglyoxal detoxification
RM02530Name: glyoxalase-1 Type: Regular Location: Mitochondria KEGG ID: R02530 click to see details on this item	4.4.1.5Name: lactoylglutathione lyase Other names: methylglyoxalase, aldoketomutase, ketone-aldehyde mutase, glyoxylase I, (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) click to see details on this item	[m] : gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item		lgt-SName: (R)-S-Lactoylglutathione Formula: C13H20N3O8S Charge: -1 click to see details on this item	glod-4	Methylglyoxal detoxification
RM01875Name: Thiosulfate:thiol sulfurtransferase Type: Regular Location: Mitochondria KEGG ID: R01875 click to see details on this item	2.8.1.3Name: thiosulfate---thiol sulfurtransferase Other names: glutathione-dependent thiosulfate reductase, sulfane reductase, sulfane sulfurtransferase click to see details on this item	[m] : so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item + h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item		tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item + (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item	Unknown	Sulfur metabolism
RC01687Name: (5-L-glutamyl)-peptide:taurine 5-glutamyltransferase Type: Regular Location: Cytosol KEGG ID: R01687 click to see details on this item	2.3.2.2Name: gamma-glutamyltransferase Other names: glutamyl transpeptidase, alpha-glutamyl transpeptidase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transpeptidase (ambiguous), gamma-GPT, gamma-GT, gamma-GTP, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase, GGT (ambiguous), gamma-glutamyltranspeptidase (ambiguous) click to see details on this item	[c] : taurName: Taurine Formula: C2H7NO3S Charge: 0 click to see details on this item + gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item		cglyName: Cys-Gly Formula: C5H10N2O3S Charge: 0 click to see details on this item + glutaurName: 5-L-Glutamyl-taurine Formula: C7H13N2O6S Charge: -1 click to see details on this item	C53D5.5 \| H14N18.4 \| T03D8.6 \| T19H12.6 \| Y7A9A.1 \| Y97E10AR.2	Taurine and hypotaurine metabolism
TCE5376Name: Reduced glutathione transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item[c]		gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item[e]	Not determined	Transport
EX00051Name: Reduced glutathione exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item[e]			Not applicable	Exchange with the environment

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