WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	lgt-S
Name .....................................................	:	(R)-S-Lactoylglutathione, etc.S-D-Lactoylglutathione
Model ID .....................................................	:	C03451
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C03451
Formula .....................................................	:	C13H20N3O8S
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	lgt-S
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Methylglyoxal detoxification (m)

iCEL1314

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ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01736Name: (R)-S-Lactoylglutathione hydrolase Type: Regular Location: Mitochondria KEGG ID: R01736 click to see details on this item	3.1.2.6Name: hydroxyacylglutathione hydrolase Other names: glyoxalase II, S-2-hydroxylacylglutathione hydrolase, hydroxyacylglutathione hydrolase, acetoacetylglutathione hydrolase click to see details on this item	[m] : lgt-SName: (R)-S-Lactoylglutathione Formula: C13H20N3O8S Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Y17G7B.3	Methylglyoxal detoxification
RM02530Name: glyoxalase-1 Type: Regular Location: Mitochondria KEGG ID: R02530 click to see details on this item	4.4.1.5Name: lactoylglutathione lyase Other names: methylglyoxalase, aldoketomutase, ketone-aldehyde mutase, glyoxylase I, (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) click to see details on this item	[m] : gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item		lgt-SName: (R)-S-Lactoylglutathione Formula: C13H20N3O8S Charge: -1 click to see details on this item	glod-4	Methylglyoxal detoxification

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