Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	lac-D
Name .....................................................	:	D-Lactate, etc.(R)-Lactate, D-Lactic acid, D-2-Hydroxypropanoic acid, D-2-Hydroxypropionic acid
Model ID .....................................................	:	C00256
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00256
Formula .....................................................	:	C3H5O3
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	lac-D
Other associations .....................................................	:	See reaction table below (6 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Methylglyoxal detoxification (c,e,m), Pyruvate metabolism (m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01736Name: (R)-S-Lactoylglutathione hydrolase Type: Regular Location: Mitochondria KEGG ID: R01736 click to see details on this item	3.1.2.6Name: hydroxyacylglutathione hydrolase Other names: glyoxalase II, S-2-hydroxylacylglutathione hydrolase, hydroxyacylglutathione hydrolase, acetoacetylglutathione hydrolase click to see details on this item	[m] : lgt-SName: (R)-S-Lactoylglutathione Formula: C13H20N3O8S Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Y17G7B.3	Methylglyoxal detoxification
RM00197Name: (R)-Lactate:ferricytochrome-c 2-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00197 click to see details on this item	1.1.2.4Name: D-lactate dehydrogenase (cytochrome) Other names: lactic acid dehydrogenase, D-lactate (cytochrome) dehydrogenase, cytochrome-dependent D-(-)-lactate dehydrogenase, D-lactate-cytochrome c reductase, D-(-)-lactic cytochrome c reductase click to see details on this item	[m] : lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item + (2) ficytCName: Ferricytochrome c Formula: C42H42FeN8O8S2R4 Charge: 1 click to see details on this item		pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item + (2) focytCName: Ferrocytochrome C Formula: C42H42FeN8O8S2R4 Charge: 0 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item	F32D8.12 & (cyc-2.1 | cyc-2.2)	Methylglyoxal detoxification
DGR0012Name: Bacterial peptidoglycan degradation Type: Degradation Location: Cytosol KEGG ID: NA click to see details on this item	To be determined	[c] : peptido_BACName: Peptidoglycan subunit of bacteria Formula: C40H62N8O21 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + (8) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		(2) acgamName: N-Acetyl-D-glucosamine Formula: C8H15NO6 Charge: 0 click to see details on this item + lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + (3) ala-LName: L-Alanine Formula: C3H7NO2 Charge: 0 click to see details on this item + lys-LName: L-Lysine Formula: C6H15N2O2 Charge: 1 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	Not determined	Bacterial digestion
TCM1279Name: D-Lactate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item[c]		lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item[m]	Not determined	Transport
TCE0716Name: D-Lactate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item[e]		lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item[c]	Not determined	Transport
EX00256Name: D-Lactate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	lac-DName: D-Lactate Formula: C3H5O3 Charge: -1 click to see details on this item[e]			Not applicable	Exchange with the environment

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