Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	gthox
Name .....................................................	:	Oxidized glutathione, etc.Glutathione disulfide, GSSG, Oxiglutatione
Model ID .....................................................	:	C00127
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00127
Formula .....................................................	:	C20H30N6O12S2
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	gthox
Other associations .....................................................	:	See reaction table below (9 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Glutathione metabolism (c,m), Sulfur metabolism (m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC07034Name: Glutathione: 5-HPETE oxidoreductase Type: Regular Location: Cytosol KEGG ID: R07034 click to see details on this item	1.11.1.9Name: glutathione peroxidase Other names: GSH peroxidase, selenium-glutathione peroxidase, reduced glutathione peroxidase click to see details on this item	[c] : (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + 5HPETName: "5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate" Formula: C20H31O4 Charge: -1 click to see details on this item		gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + 5HETEName: 5-Hydroxyeicosatetraenoate Formula: C20H31O3 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	gpx-1 | gpx-2 | gpx-3 | gpx-4 | gpx-5 | gpx-7 | gpx-8	Arachidonic acid metabolism
RC00115Name: glutathione:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00115 click to see details on this item	1.8.1.7Name: glutathione-disulfide reductase Other names: glutathione reductase, glutathione reductase (NADPH), NADPH-glutathione reductase, GSH reductase, GSSG reductase, NADPH-GSSG reductase, glutathione S-reductase, NADPH:oxidized-glutathione oxidoreductase click to see details on this item	[c] : gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	gsr-1	Glutathione metabolism
RC00274Name: glutathione:hydrogen-peroxide oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00274 click to see details on this item	1.11.1.9Name: glutathione peroxidase Other names: GSH peroxidase, selenium-glutathione peroxidase, reduced glutathione peroxidase click to see details on this item	[c] : (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item		gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	gpx-1 | gpx-2 | gpx-3 | gpx-4 | gpx-5 | gpx-7 | gpx-8	Glutathione metabolism
RM00115Name: glutathione:NADP+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00115 click to see details on this item	1.8.1.7Name: glutathione-disulfide reductase Other names: glutathione reductase, glutathione reductase (NADPH), NADPH-glutathione reductase, GSH reductase, GSSG reductase, NADPH-GSSG reductase, glutathione S-reductase, NADPH:oxidized-glutathione oxidoreductase click to see details on this item	[m] : gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	trxr-2	Glutathione metabolism
RC01108Name: glutathione dehydrogenase (ascorbate) Type: Regular Location: Cytosol KEGG ID: R01108 click to see details on this item	1.8.5.1Name: glutathione dehydrogenase (ascorbate) Other names: dehydroascorbic reductase, dehydroascorbic acid reductase, glutathione dehydroascorbate reductase, DHA reductase , dehydroascorbate reductase, GDOR, glutathione:dehydroascorbic acid oxidoreductase click to see details on this item	[c] : dhdascbName: Dehydroascorbate Formula: C6H6O6 Charge: 0 click to see details on this item + (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item		ascb-LName: L-Ascorbate Formula: C6H8O6 Charge: 0 click to see details on this item + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item	Unknown	Glutathione metabolism
RM01875Name: Thiosulfate:thiol sulfurtransferase Type: Regular Location: Mitochondria KEGG ID: R01875 click to see details on this item	2.8.1.3Name: thiosulfate---thiol sulfurtransferase Other names: glutathione-dependent thiosulfate reductase, sulfane reductase, sulfane sulfurtransferase click to see details on this item	[m] : so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item + h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item		tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item + (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item	Unknown	Sulfur metabolism
TCE5402Name: Oxidized glutathione active transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item[c] + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item[c] + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item[c]		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item[c] + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item[e] + hName: H+ Formula: H Charge: 1 click to see details on this item[c] + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item[c]	Not determined	Transport
TCE1148Name: Oxidized glutathione transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item[e]		gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item[c]	Not determined	Transport
EX00127Name: Oxidized glutathione exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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