Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Pathway Overview

Name .....................................................	:	Sphingolipid metabolism
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	23
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	Sphingolipid metabolism

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC04183Name: alpha-N-Acetyl-D-galactosaminide N-acetylgalactosaminohydrolase Type: Regular Location: Cytosol KEGG ID: R04183 click to see details on this item	3.2.1.49Name: alpha-N-acetylgalactosaminidase Other names: alpha-acetylgalactosaminidase, N-acetyl-alpha-D-galactosaminidase, N-acetyl-alpha-galactosaminidase, alpha-NAGAL, alpha-NAGA, alpha-GalNAcase click to see details on this item	[c] : gbside_ceName: globoside Formula: C45H81N2O22FULLRCO Charge: 0 click to see details on this item + acgalName: N-Acetyl-D-galactosamine Formula: C8H15NO6 Charge: 0 click to see details on this item		forssman_ceName: Forssman hapten Formula: C54H94N3O28R Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	gana-1	Sphingolipid metabolism
RC04184Name: Trihexosylceramide N-acetylhexosaminohydrolase Type: Regular Location: Cytosol KEGG ID: R04184 click to see details on this item	3.2.1.52Name: beta-N-acetylhexosaminidase Other names: hexosaminidase, beta-acetylaminodeoxyhexosidase, N-acetyl-beta-D-hexosaminidase, N-acetyl-beta-hexosaminidase, beta-hexosaminidase, beta-acetylhexosaminidinase, beta-D-N-acetylhexosaminidase, beta-N-acetyl-D-hexosaminidase, beta-N-acetylglucosaminidase, hexosaminidase A, N-acetylhexosaminidase, beta-D-hexosaminidase click to see details on this item	[c] : thcrm_ceName: trihexosyl ceramide Formula: C37H68NO17FULLRCO Charge: 0 click to see details on this item + acgalName: N-Acetyl-D-galactosamine Formula: C8H15NO6 Charge: 0 click to see details on this item		gbside_ceName: globoside Formula: C45H81N2O22FULLRCO Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	hex-1 | hex-2 | hex-3 | hex-4 | hex-5	Sphingolipid metabolism
RC06517Name: acyl-CoA:sphingosine N-acyltransferase Type: Regular Location: Cytosol KEGG ID: R06517 click to see details on this item	2.3.1.24Name: sphingosine N-acyltransferase Other names: ceramide synthetase, sphingosine acyltransferase click to see details on this item	[c] : RtotalcoaName: R total Coenzyme A Formula: CO2FULLRC21H31N7O15P3S Charge: -4 click to see details on this item + sphgn_ceName: Sphinganine Formula: C19H42NO2 Charge: 1 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + dhcrm_ceName: dihydroceramide Formula: C19H40NO2FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	hyl-1 | hyl-2 | lagr-1	Sphingolipid metabolism
RC06518Name: N-acylsphingosine amidohydrolase Type: Regular Location: Cytosol KEGG ID: R06518 click to see details on this item	3.5.1.23Name: ceramidase Other names: acylsphingosine deacylase, glycosphingolipid ceramide deacylase click to see details on this item	[c] : dhcrm_ceName: dihydroceramide Formula: C19H40NO2FULLRCO Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		RtotalName: R total Formula: CO2FULLR Charge: -1 click to see details on this item + sphgn_ceName: Sphinganine Formula: C19H42NO2 Charge: 1 click to see details on this item	W02F12.2	Sphingolipid metabolism
RC06519Name: sphingolipid delta-4 desaturase Type: Regular Location: Cytosol KEGG ID: R06519 click to see details on this item	1.14.-.-Name: sphingolipid delta-4 desaturase Other names: sphingolipid delta-4 desaturase click to see details on this item	[c] : dhcrm_ceName: dihydroceramide Formula: C19H40NO2FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	F33D4.4 | ttm-5	Sphingolipid metabolism
RCC0060Name: sphingolipid delta-4 desaturase Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	1.14.-.-Name: sphingolipid delta-4 desaturase Other names: sphingolipid delta-4 desaturase click to see details on this item	[c] : dhcrm_ceName: dihydroceramide Formula: C19H40NO2FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	F33D4.4 | ttm-5	Sphingolipid metabolism
RC01496Name: Acyl-CoA:sphingosine N-acyltransferase Type: Regular Location: Cytosol KEGG ID: R01496 click to see details on this item	2.3.1.24Name: sphingosine N-acyltransferase Other names: ceramide synthetase, sphingosine acyltransferase click to see details on this item	[c] : RtotalcoaName: R total Coenzyme A Formula: CO2FULLRC21H31N7O15P3S Charge: -4 click to see details on this item + sphings_ceName: Sphingosine Formula: C19H40NO2 Charge: 1 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	hyl-1 | hyl-2 | lagr-1	Sphingolipid metabolism
RC01494Name: N-Acylsphingosine amidohydrolase Type: Regular Location: Cytosol KEGG ID: R01494 click to see details on this item	3.5.1.23Name: ceramidase Other names: acylsphingosine deacylase, glycosphingolipid ceramide deacylase click to see details on this item	[c] : crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		RtotalName: R total Formula: CO2FULLR Charge: -1 click to see details on this item + sphings_ceName: Sphingosine Formula: C19H40NO2 Charge: 1 click to see details on this item	W02F12.2 | (asah-2 | asah-1)	Sphingolipid metabolism
RC08969Name: ceramide:phosphatidylcholine cholinephosphotransferase Type: Regular Location: Cytosol KEGG ID: R08969 click to see details on this item	2.7.8.27Name: sphingomyelin synthase Other names: SM synthase, SMS1, SMS2 click to see details on this item	[c] : crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + pcholName: Phosphatidylcholine Formula: C8H18NO4PFULLRCO2FULLR2CO2 Charge: 0 click to see details on this item		dag_plName: diacylglycerol (phospholipids) Formula: C3H6OFULLRCO2FULLR2CO2 Charge: 0 click to see details on this item + sphmyln_ceName: Sphingomyelin Formula: C24H50N2O5PFULLRCO Charge: 0 click to see details on this item	W07E6.3 | sms-1 | sms-2 | sms-3	Sphingolipid metabolism
RC02541Name: Sphingomyelin cholinephosphohydrolase Type: Regular Location: Cytosol KEGG ID: R02541 click to see details on this item	3.1.4.12Name: sphingomyelin phosphodiesterase Other names: neutral sphingomyelinase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + sphmyln_ceName: Sphingomyelin Formula: C24H50N2O5PFULLRCO Charge: 0 click to see details on this item		cholpName: Choline phosphate Formula: C5H13NO4P Charge: -1 click to see details on this item + crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	(asm-1 | asm-2 | asm-3) | T27F6.6 | R05D11.9	Sphingolipid metabolism
RC02543Name: Acyl-CoA:sphingosylphosphorylcholine N-acyltransferase Type: Regular Location: Cytosol KEGG ID: R02543 click to see details on this item	2.3.1.24Name: sphingosine N-acyltransferase Other names: ceramide synthetase, sphingosine acyltransferase click to see details on this item	[c] : RtotalcoaName: R total Coenzyme A Formula: CO2FULLRC21H31N7O15P3S Charge: -4 click to see details on this item + spc_ceName: sphingosylphosphorylcholine Formula: C24H52N2O5P Charge: 1 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + sphmyln_ceName: Sphingomyelin Formula: C24H50N2O5PFULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	hyl-1 | hyl-2 | lagr-1	Sphingolipid metabolism
RC01495Name: ATP:ceramide 1-phosphotransferase Type: Regular Location: Cytosol KEGG ID: R01495 click to see details on this item	2.7.1.138Name: ceramide kinase Other names: acylsphingosine kinase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + crmp_ceName: Ceramide 1-phosphate Formula: C19H37NO5PFULLRCO Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	cerk-1	Sphingolipid metabolism
RC06522Name: Ceramide 1-phosphate phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R06522 click to see details on this item	3.1.3.4Name: phosphatidate phosphatase Other names: phosphatic acid phosphatase, acid phosphatidyl phosphatase, phosphatic acid phosphohydrolase, PAP, Lipin click to see details on this item	[c] : crmp_ceName: Ceramide 1-phosphate Formula: C19H37NO5PFULLRCO Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	F13E6.5 | F53C3.13 | T28D9.3	Sphingolipid metabolism
RC01497Name: UDP-glucose:N-acylsphingosine D-glucosyltransferase Type: Regular Location: Cytosol KEGG ID: R01497 click to see details on this item	2.4.1.80Name: ceramide glucosyltransferase Other names: UDP-glucose:ceramide glucosyltransferase, ceramide:UDP-Glc glucosyltransferase, uridine diphosphoglucose-ceramide glucosyltransferase, ceramide:UDP-glucose glucosyltransferase, glucosylceramide synthase click to see details on this item	[c] : crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + udpgName: UDPglucose Formula: C15H22N2O17P2 Charge: -2 click to see details on this item		gluside_ceName: glucocerebroside Formula: C25H48NO7FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + udpName: UDP Formula: C9H11N2O12P2 Charge: -3 click to see details on this item	cgt-1 | cgt-2 | cgt-3	Sphingolipid metabolism
RC01498Name: D-Glucosyl-N-acylsphingosine glucohydrolase Type: Regular Location: Cytosol KEGG ID: R01498 click to see details on this item	3.2.1.45Name: glucosylceramidase Other names: psychosine hydrolase, glucosphingosine glucosylhydrolase, GlcCer-beta-glucosidase, beta-D-glucocerebrosidase, glucosylcerebrosidase, beta-glucosylceramidase, ceramide glucosidase, glucocerebrosidase, glucosylsphingosine beta-glucosidase, glucosylsphingosine beta-D-glucosidase click to see details on this item	[c] : gluside_ceName: glucocerebroside Formula: C25H48NO7FULLRCO Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + glc-DName: D-Glucose Formula: C6H12O6 Charge: 0 click to see details on this item	(R08F11.1 | hpo-13) | (gba-1 | gba-2 | gba-3 | gba-4)	Sphingolipid metabolism
RC02464Name: Sphinganine-1-phosphate pamlmitaldehyde-lyase Type: Regular Location: Cytosol KEGG ID: R02464 click to see details on this item	4.1.2.27Name: sphinganine-1-phosphate aldolase Other names: dihydrosphingosine 1-phosphate aldolase, sphinganine-1-phosphate alkanal-lyase, sphinganine-1-phosphate lyase, sphinganine-1-phosphate palmitaldehyde-lyase click to see details on this item	[c] : sph1p_ceName: Sphinganine 1-phosphate Formula: C19H41NO5P Charge: -1 click to see details on this item		ethampName: Ethanolamine phosphate Formula: C2H7NO4P Charge: -1 click to see details on this item + m15hxdcalName: 15-methylhexadecanal Formula: C17H34O Charge: 0 click to see details on this item	spl-1 | tag-38	Sphingolipid metabolism
RC01926Name: sphingosine kinase Type: Regular Location: Cytosol KEGG ID: R01926 click to see details on this item	2.7.1.91Name: sphinganine kinase Other names: dihydrosphingosine kinase, dihydrosphingosine kinase (phosphorylating), sphingosine kinase (phosphorylating) click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + sphings_ceName: Sphingosine Formula: C19H40NO2 Charge: 1 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + sphs1p_ceName: Sphingosine 1-phosphate Formula: C19H39NO5P Charge: -1 click to see details on this item	sphk-1	Sphingolipid metabolism
RC02976Name: sphinganine kinase Type: Regular Location: Cytosol KEGG ID: R02976 click to see details on this item	2.7.1.91Name: sphinganine kinase Other names: dihydrosphingosine kinase, dihydrosphingosine kinase (phosphorylating), sphingosine kinase (phosphorylating) click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + sphgn_ceName: Sphinganine Formula: C19H42NO2 Charge: 1 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + sph1p_ceName: Sphinganine 1-phosphate Formula: C19H41NO5P Charge: -1 click to see details on this item	sphk-1	Sphingolipid metabolism
RC02978Name: 3-dehydrosphinganine reductase Type: Regular Location: Cytosol KEGG ID: R02978 click to see details on this item	1.1.1.102Name: 3-dehydrosphinganine reductase Other names: D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, DSR, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, D-3-oxosphinganine:B-NADPH oxidoreductase click to see details on this item	[c] : 3dsphgn_ceName: 3-Dehydrosphinganine Formula: C19H40NO2 Charge: 1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + sphgn_ceName: Sphinganine Formula: C19H42NO2 Charge: 1 click to see details on this item	To be determined	Sphingolipid metabolism
RC06520Name: Sphinganine 1-phosphate phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R06520 click to see details on this item	3.1.3.4Name: phosphatidate phosphatase Other names: phosphatic acid phosphatase, acid phosphatidyl phosphatase, phosphatic acid phosphohydrolase, PAP, Lipin click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + sph1p_ceName: Sphinganine 1-phosphate Formula: C19H41NO5P Charge: -1 click to see details on this item		piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + sphgn_ceName: Sphinganine Formula: C19H42NO2 Charge: 1 click to see details on this item	F13E6.5 | F53C3.13 | T28D9.3	Sphingolipid metabolism
RC06521Name: Sphingosine 1-phosphate phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R06521 click to see details on this item	3.1.3.4Name: phosphatidate phosphatase Other names: phosphatic acid phosphatase, acid phosphatidyl phosphatase, phosphatic acid phosphohydrolase, PAP, Lipin click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + sphs1p_ceName: Sphingosine 1-phosphate Formula: C19H39NO5P Charge: -1 click to see details on this item		piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + sphings_ceName: Sphingosine Formula: C19H40NO2 Charge: 1 click to see details on this item	F13E6.5 | F53C3.13 | T28D9.3	Sphingolipid metabolism
RC03617Name: D-galactosyl-N-acylsphingosine galactohydrolase Type: Regular Location: Cytosol KEGG ID: R03617 click to see details on this item	3.2.1.46Name: galactosylceramidase Other names: cerebroside galactosidase, galactocerebroside.beta-galactosidase, galactosylcerebrosidase, galactocerebrosidase, ceramide galactosidase, galactocerebroside galactosidase, galactosylceramide.beta-galactosidase, cerebroside beta-galactosidase, galactosylceramidase I, beta-galactosylceramidase, galactocerebroside-beta-D-galactosidase, lactosylceramidase I, beta-galactocerebrosidase, lactosylceramidase click to see details on this item	[c] : galside_ceName: galactocerebroside Formula: C25H48NO7FULLRCO Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item + galName: D-Galactose Formula: C6H12O6 Charge: 0 click to see details on this item	C29E4.10	Sphingolipid metabolism
RC01500Name: UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase Type: Regular Location: Cytosol KEGG ID: R01500 click to see details on this item	2.7.1.47Name: D-ribulokinase Other names: D-ribulokinase (phosphorylating) click to see details on this item	[c] : udpgalName: UDPgalactose Formula: C15H22N2O17P2 Charge: -2 click to see details on this item + crm_ceName: ceramide Formula: C19H38NO2FULLRCO Charge: 0 click to see details on this item		udpName: UDP Formula: C9H11N2O12P2 Charge: -3 click to see details on this item + galside_ceName: galactocerebroside Formula: C25H48NO7FULLRCO Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	To be determined	Sphingolipid metabolism

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