Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Pathway Overview

Name .....................................................	:	Nicotinate and nicotinamide metabolism
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	18
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	Nicotinate and nicotinamide metabolism

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM00112Name: NADPH:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00112 click to see details on this item	1.6.1.2Name: NAD(P)+ transhydrogenase (Re/Si-specific) Other names: pyridine nucleotide transhydrogenase, transhydrogenase, NAD(P)+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, NAD+ transhydrogenase, NADH transhydrogenase, nicotinamide nucleotide transhydrogenase, NADPH-NAD+ transhydrogenase, pyridine nucleotide transferase, NADPH-NAD+ oxidoreductase, NADH-NADP+-transhydrogenase, NADPH:NAD+ transhydrogenase, H+-Thase, energy-linked transhydrogenase, NAD(P) transhydrogenase (AB-specific), NAD(P)+ transhydrogenase (AB-specific), NADPH:NAD+ oxidoreductase (AB-specific) click to see details on this item	[m] : nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	nnt-1	Nicotinate and nicotinamide metabolism
RC02294Name: N-Ribosylnicotinamide:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02294 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + rnamName: N-Ribosylnicotinamide Formula: C11H15N2O5 Charge: 1 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item	K02D7.1	Nicotinate and nicotinamide metabolism
RC02295Name: Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02295 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + nacName: Nicotinate Formula: C6H4NO2 Charge: -1 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item		nicrnsName: Nicotinate D-ribonucleoside Formula: C11H13NO6 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	K02D7.1	Nicotinate and nicotinamide metabolism
RC02323Name: Nicotinamide ribonucleotide phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R02323 click to see details on this item	3.1.3.5Name: 5'-nucleotidase Other names: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nmnName: NMN Formula: C11H14N2O8P Charge: -1 click to see details on this item		rnamName: N-Ribosylnicotinamide Formula: C11H15N2O5 Charge: 1 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	F25B5.3 | Y10G11A.1 | Y71H10B.1	Nicotinate and nicotinamide metabolism
RC03346Name: Nicotinate D-ribonucleotide phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R03346 click to see details on this item	3.1.3.5Name: 5'-nucleotidase Other names: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nicrntName: Nicotinate D-ribonucleotide Formula: C11H12NO9P Charge: -2 click to see details on this item		nicrnsName: Nicotinate D-ribonucleoside Formula: C11H13NO6 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	F25B5.3 | Y10G11A.1 | Y71H10B.1	Nicotinate and nicotinamide metabolism
RC01724Name: Nicotinate D-ribonucleotide:diphosphate phosphoribosyltransferase Type: Regular Location: Cytosol KEGG ID: R01724 click to see details on this item	6.3.4.21Name: nicotinate phosphoribosyltransferase Other names: niacin ribonucleotidase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, nicotinic acid phosphoribosyltransferase, nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + nacName: Nicotinate Formula: C6H4NO2 Charge: -1 click to see details on this item + prppName: 5-Phospho-alpha-D-ribose 1-diphosphate Formula: C5H8O14P3 Charge: -5 click to see details on this item		nicrntName: Nicotinate D-ribonucleotide Formula: C11H12NO9P Charge: -2 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	nprt-1	Nicotinate and nicotinamide metabolism
RC00137Name: ATP:nicotinamide-nucleotide adenylyltransferase Type: Regular Location: Cytosol KEGG ID: R00137 click to see details on this item	2.7.7.1Name: nicotinamide-nucleotide adenylyltransferase Other names: NAD+ pyrophosphorylase, adenosine triphosphate-nicotinamide mononucleotide transadenylase, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyltransferase, NMN adenylyltransferase click to see details on this item 2.7.7.18Name: nicotinate-nucleotide adenylyltransferase Other names: deamido-NAD+ pyrophosphorylase, nicotinate mononucleotide adenylyltransferase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, NaMN-ATase, nicotinic acid mononucleotide adenylyltransferase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nmnName: NMN Formula: C11H14N2O8P Charge: -1 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	nmat-1 | nmat-2	Nicotinate and nicotinamide metabolism
RC03005Name: ATP:nicotinamide-nucleotide adenylyltransferase Type: Regular Location: Cytosol KEGG ID: R03005 click to see details on this item	2.7.7.1Name: nicotinamide-nucleotide adenylyltransferase Other names: NAD+ pyrophosphorylase, adenosine triphosphate-nicotinamide mononucleotide transadenylase, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyltransferase, NMN adenylyltransferase click to see details on this item 2.7.7.18Name: nicotinate-nucleotide adenylyltransferase Other names: deamido-NAD+ pyrophosphorylase, nicotinate mononucleotide adenylyltransferase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, NaMN-ATase, nicotinic acid mononucleotide adenylyltransferase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nicrntName: Nicotinate D-ribonucleotide Formula: C11H12NO9P Charge: -2 click to see details on this item		dnadName: Deamino-NAD+ Formula: C21H24N6O15P2 Charge: -2 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	nmat-1 | nmat-2	Nicotinate and nicotinamide metabolism
RC00257Name: Deamido-NAD+:L-glutamine amido-ligase (AMP-forming) Type: Regular Location: Cytosol KEGG ID: R00257 click to see details on this item	6.3.5.1Name: NAD+ synthase (glutamine-hydrolysing) Other names: NAD synthetase (glutamine-hydrolysing), nicotinamide adenine dinucleotide synthetase (glutamine), desamidonicotinamide adenine dinucleotide amidotransferase, DPN synthetase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + dnadName: Deamino-NAD+ Formula: C21H24N6O15P2 Charge: -2 click to see details on this item + gln-LName: L-Glutamine Formula: C5H10N2O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	qns-1	Nicotinate and nicotinamide metabolism
RC01268Name: nicotinamidase Type: Regular Location: Cytosol KEGG ID: R01268 click to see details on this item	3.5.1.19Name: nicotinamidase Other names: nicotinamide deaminase, nicotinamide amidase, YNDase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item		nacName: Nicotinate Formula: C6H4NO2 Charge: -1 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item	pnc-1 | pnc-2	Nicotinate and nicotinamide metabolism
RC00102Name: NAD nucleosidase Type: Regular Location: Cytosol KEGG ID: R00102 click to see details on this item	3.5.1.-Name: nAD nucleosidase Other names: nAD-dependent histone deacetylase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		adpribName: ADPribose Formula: C15H21N5O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item	sir-2.1 | sir-2.2 | sir-2.3 | sir-2.4	Nicotinate and nicotinamide metabolism
RC04176Name: NAD+:poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase (PARP) Type: Regular Location: Cytosol KEGG ID: R04176 click to see details on this item	2.4.2.30Name: NAD+ ADP-ribosyltransferase Other names: poly(ADP-ribose) synthase, ADP-ribosyltransferase (polymerizing), NAD ADP-ribosyltransferase, PARP, PARP-1, NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase (incorrect), NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase click to see details on this item	[c] : nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		polyadpribName: poly adp ribose Formula: C15H19N5O13P2 Charge: -2 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	parp-1 | parp-2 | tank-1	Nicotinate and nicotinamide metabolism
RCC0051Name: poly(ADP-ribose) glycohydrolase (PARG) Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	3.2.1.143Name: poly(ADP-ribose) glycohydrolase click to see details on this item	[c] : polyadpribName: poly adp ribose Formula: C15H19N5O13P2 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		adpribName: ADPribose Formula: C15H21N5O14P2 Charge: -2 click to see details on this item	parg-1 | parg-2	Nicotinate and nicotinamide metabolism
RC03004Name: Deaminido NAD diphosphatase Type: Regular Location: Cytosol KEGG ID: R03004 click to see details on this item	3.6.1.9Name: nucleotide diphosphatase Other names: nucleotide pyrophosphatase, nucleotide-sugar pyrophosphatase click to see details on this item	[c] : dnadName: Deamino-NAD+ Formula: C21H24N6O15P2 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nicrntName: Nicotinate D-ribonucleotide Formula: C11H12NO9P Charge: -2 click to see details on this item	C27A7.1 | C27A7.3	Nicotinate and nicotinamide metabolism
RC00103Name: NAD+ phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R00103 click to see details on this item	3.6.1.9Name: nucleotide diphosphatase Other names: nucleotide pyrophosphatase, nucleotide-sugar pyrophosphatase click to see details on this item	[c] : nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nmnName: NMN Formula: C11H14N2O8P Charge: -1 click to see details on this item	C27A7.1 | C27A7.3	Nicotinate and nicotinamide metabolism
RC10633Name: NAD-dependent histone deacetylase Type: Regular Location: Cytosol KEGG ID: R10633 click to see details on this item	3.5.1.-Name: nAD nucleosidase Other names: nAD-dependent histone deacetylase click to see details on this item	[c] : nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + NaclysName: Histone N6-acetyl-L-lysine Formula: XC8H14N2O2 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + NlysName: Histone-L-Lysine Formula: XC6H13N2O Charge: 1 click to see details on this item + ac_adpribName: O-Acetyl-ADP-ribose Formula: C17H23N5O15P2 Charge: -2 click to see details on this item	sir-2.1 | sir-2.2 | sir-2.3 | sir-2.4	Nicotinate and nicotinamide metabolism
RC01269Name: S-Adenosyl-L-methionine:nicotinamide N-methyltransferase Type: Regular Location: Cytosol KEGG ID: R01269 click to see details on this item	2.1.1.1Name: nicotinamide N-methyltransferase Other names: nicotinamide methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + 1mncamName: 1-Methylnicotinamide Formula: C7H9N2O Charge: 1 click to see details on this item	anmt-1 | anmt-3	Nicotinate and nicotinamide metabolism
RC03348Name: Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating) Type: Regular Location: Cytosol KEGG ID: R03348 click to see details on this item	2.4.2.19Name: nicotinate-nucleotide diphosphorylase (carboxylating) Other names: quinolinate phosphoribosyltransferase (decarboxylating), quinolinic acid phosphoribosyltransferase, QAPRTase, NAD+ pyrophosphorylase, nicotinate mononucleotide pyrophosphorylase (carboxylating), quinolinic phosphoribosyltransferase click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + prppName: 5-Phospho-alpha-D-ribose 1-diphosphate Formula: C5H8O14P3 Charge: -5 click to see details on this item + qulnName: Quinolinate Formula: C7H3NO4 Charge: -2 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nicrntName: Nicotinate D-ribonucleotide Formula: C11H12NO9P Charge: -2 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	umps-1	Nicotinate and nicotinamide metabolism

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