WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	2.4.2.1
Name .....................................................	:	Purine-nucleoside phosphorylase, etc.Inosine phosphorylase, PNPase, PUNPI, PUNPII, Inosine-guanosine phosphorylase, Nucleotide phosphatase, Purine deoxynucleoside phosphorylase, Purine deoxyribonucleoside phosphorylase, Purine nucleoside phosphorylase, Purine ribonucleoside phosphorylase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K03783punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
Genes .....................................................	:	K02D7.1
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below (10 reactions in total)

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC02294Name: N-Ribosylnicotinamide:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02294 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + rnamName: N-Ribosylnicotinamide Formula: C11H15N2O5 Charge: 1 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item	K02D7.1	Nicotinate and nicotinamide metabolism
RC02295Name: Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02295 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + nacName: Nicotinate Formula: C6H4NO2 Charge: -1 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item		nicrnsName: Nicotinate D-ribonucleoside Formula: C11H13NO6 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	K02D7.1	Nicotinate and nicotinamide metabolism
RC01863Name: inosine:phosphate alpha-D-ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R01863 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : insName: Inosine Formula: C10H12N4O5 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		hxanName: Hypoxanthine Formula: C5H4N4O Charge: 0 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item	K02D7.1	Purine metabolism
RC01561Name: Adenosine:phosphate alpha-D-ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R01561 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : adnName: Adenosine Formula: C10H13N5O4 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		adeName: Adenine Formula: C5H5N5 Charge: 0 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item	K02D7.1	Purine metabolism
RC02748Name: Deoxyinosine:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02748 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : dinName: Deoxyinosine Formula: C10H12N4O4 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		2dr1pName: 2-Deoxy-D-ribose 1-phosphate Formula: C5H9O7P Charge: -2 click to see details on this item + hxanName: Hypoxanthine Formula: C5H4N4O Charge: 0 click to see details on this item	K02D7.1	Purine metabolism
RC02557Name: Deoxyadenosine:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02557 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : dad-2Name: Deoxyadenosine Formula: C10H13N5O3 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		2dr1pName: 2-Deoxy-D-ribose 1-phosphate Formula: C5H9O7P Charge: -2 click to see details on this item + adeName: Adenine Formula: C5H5N5 Charge: 0 click to see details on this item	K02D7.1	Purine metabolism
RC02297Name: Xanthosine:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02297 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + xtsnName: Xanthosine Formula: C10H12N4O6 Charge: 0 click to see details on this item		r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item + xanName: Xanthine Formula: C5H4N4O2 Charge: 0 click to see details on this item	K02D7.1	Purine metabolism
RC02147Name: guanosine:phosphate alpha-D-ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02147 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : gsnName: Guanosine Formula: C10H13N5O5 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		guaName: Guanine Formula: C5H5N5O Charge: 0 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item	K02D7.1	Purine metabolism
RC01969Name: Deoxyguanosine:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R01969 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : dgsnName: Deoxyguanosine Formula: C10H13N5O4 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		2dr1pName: 2-Deoxy-D-ribose 1-phosphate Formula: C5H9O7P Charge: -2 click to see details on this item + guaName: Guanine Formula: C5H5N5O Charge: 0 click to see details on this item	K02D7.1	Purine metabolism
RC02484Name: deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02484 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item 2.4.2.3Name: uridine phosphorylase Other names: pyrimidine phosphorylase, UrdPase, UPH, UPase click to see details on this item	[c] : duriName: Deoxyuridine Formula: C9H12N2O5 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item		2dr1pName: 2-Deoxy-D-ribose 1-phosphate Formula: C5H9O7P Charge: -2 click to see details on this item + uraName: Uracil Formula: C4H4N2O2 Charge: 0 click to see details on this item	K02D7.1 \| upp-1	Pyrimidine metabolism

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