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Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
FBAFlux Balance Analysis PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network
Metabolite Overview
Abbreviation ..................................................... : Nlys
Name ..................................................... : Histone-L-Lysine
Model ID ..................................................... : C02415
KEGG ID (?) Compounds in KEGG database that match this compound. ..................................................... : C02415
Formula ..................................................... : XC6H13N2O
Charge ..................................................... : +1
Localization ..................................................... : Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. ..................................................... : peplys
Other associations ..................................................... : See reaction table below (7 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here.

Letters after map name indicate the compartments the metabolite is placed in the map:

(c) Cytosol
(m) Mitochondria
(e) Extracellular space ..................................................... 		: Nicotinate and nicotinamide metabolism (c,e)
Comments
  • Based on peplys.

    • Reactions
    ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

    I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
    & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

    If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.     		Pathway
    RC03875Name: S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
    Type: Regular
    Location: Cytosol
    KEGG ID: R03875

    click to see details on this item
    2.1.1.43Name: histone-lysine N-methyltransferase
    Other names: protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase

    click to see details on this item
    [c] : ametName: S-Adenosyl-L-methionine
    Formula: C15H23N6O5S
    Charge: 1




    click to see details on this item     + NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item
    NmelysName: Histone N6-methyl-L-lysine
    Formula: XC7H15N2O
    Charge: 1




    click to see details on this item     + ahcysName: S-Adenosyl-L-homocysteine
    Formula: C14H20N6O5S
    Charge: 0




    click to see details on this item     + hName: H+
    Formula: H
    Charge: 1




    click to see details on this item
    [set-16 | lin-59 | (met-1 | set-12) | set-2 | met-2 | set-11 | mes-2 | set-23 | (dot-1.1 | dot-1.2 | dot-1.3 | dot-1.4 | dot-1.5) | set-4 | set-1] | [set-13 | set-15 | set-21 | set-32 | set-33 | set-6]
    Histone modification
    RC03552Name: Acetyl-CoA:histone acetyltransferase
    Type: Regular
    Location: Cytosol
    KEGG ID: R03552

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    2.3.1.48Name: histone acetyltransferase
    Other names: nucleosome-histone acetyltransferase, histone acetokinase, histone acetylase, histone transacetylase

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    [c] : accoaName: Acetyl-CoA
    Formula: C23H34N7O17P3S
    Charge: -4




    click to see details on this item     + NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item
    coaName: Coenzyme A
    Formula: C21H32N7O16P3S
    Charge: -4




    click to see details on this item     + NaclysName: Histone N6-acetyl-L-lysine
    Formula: XC8H14N2O2
    Charge: 0




    click to see details on this item     + hName: H+
    Formula: H
    Charge: 1




    click to see details on this item
    [(C49F5.5 | cbp-1) | lsy-12 | mys-1 | oga-1 | hat-1 | elpc-3 | mys-2 | pcaf-1] | mys-4
    Histone modification
    RC09511Name: protein-N6-methyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
    Type: Regular
    Location: Cytosol
    KEGG ID: R09511

    click to see details on this item
    1.14.11.27Name: [histone-H3]-lysine-36 demethylase
    Other names: JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase

    click to see details on this item
    [c] : NmelysName: Histone N6-methyl-L-lysine
    Formula: XC7H15N2O
    Charge: 1




    click to see details on this item     + akgName: 2-Oxoglutarate
    Formula: C5H4O5
    Charge: -2




    click to see details on this item     + o2Name: O2
    Formula: O2
    Charge: 0




    click to see details on this item
    NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item     + succName: Succinate
    Formula: C4H4O4
    Charge: -2




    click to see details on this item     + faldName: Formaldehyde
    Formula: CH2O
    Charge: 0




    click to see details on this item     + co2Name: CO2
    Formula: CO2
    Charge: 0




    click to see details on this item
    jhdm-1
    Histone modification
    RC10633Name: NAD-dependent histone deacetylase
    Type: Regular
    Location: Cytosol
    KEGG ID: R10633

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    3.5.1.-Name: nAD nucleosidase
    Other names: nAD-dependent histone deacetylase

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    [c] : nadName: Nicotinamide adenine dinucleotide
    Formula: C21H26N7O14P2
    Charge: -1




    click to see details on this item     + NaclysName: Histone N6-acetyl-L-lysine
    Formula: XC8H14N2O2
    Charge: 0




    click to see details on this item     + h2oName: H2O
    Formula: H2O
    Charge: 0




    click to see details on this item
    ncamName: Nicotinamide
    Formula: C6H6N2O
    Charge: 0




    click to see details on this item     + NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item     + ac_adpribName: O-Acetyl-ADP-ribose
    Formula: C17H23N5O15P2
    Charge: -2




    click to see details on this item
    sir-2.1 | sir-2.2 | sir-2.3 | sir-2.4
    Nicotinate and nicotinamide metabolism
    SNK0071Name: non-methylated histone sink
    Type: Sink
    Location: Cytosol
    KEGG ID: NA

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    Not applicable
    NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item    [c]
    Not applicable
    Sink reactions
    TCE2003Name: Histone-L-Lysine transport
    Type: Transport
    Location: Cytosol, Extracellular
    KEGG ID: NA

    click to see details on this item
    Not applicable
    NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item    [e]
    NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item    [c]
    Not determined
    Transport
    EX02415Name: Histone-L-Lysine exchange
    Type: Exchange
    Location: Extracellular
    KEGG ID: NA

    click to see details on this item
    Not applicable
    NlysName: Histone-L-Lysine
    Formula: XC6H13N2O
    Charge: 1




    click to see details on this item    [e]
    Not applicable
    Exchange with the environment
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