Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	ncam
Name .....................................................	:	Nicotinamide, etc.Nicotinic acid amide, Niacinamide, Vitamin PP
Model ID .....................................................	:	C00153
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00153
Formula .....................................................	:	C6H6N2O
Charge .....................................................	:	0
Localization .....................................................	:	Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	ncam
Other associations .....................................................	:	See reaction table below (8 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Nicotinate and nicotinamide metabolism (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC02294Name: N-Ribosylnicotinamide:orthophosphate ribosyltransferase Type: Regular Location: Cytosol KEGG ID: R02294 click to see details on this item	2.4.2.1Name: purine-nucleoside phosphorylase Other names: inosine phosphorylase, PNPase, PUNPI, PUNPII, inosine-guanosine phosphorylase, nucleotide phosphatase, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside phosphorylase, purine ribonucleoside phosphorylase click to see details on this item	[c] : piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + rnamName: N-Ribosylnicotinamide Formula: C11H15N2O5 Charge: 1 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + r1pName: alpha-D-Ribose 1-phosphate Formula: C5H9O8P Charge: -2 click to see details on this item	K02D7.1	Nicotinate and nicotinamide metabolism
RC01268Name: nicotinamidase Type: Regular Location: Cytosol KEGG ID: R01268 click to see details on this item	3.5.1.19Name: nicotinamidase Other names: nicotinamide deaminase, nicotinamide amidase, YNDase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item		nacName: Nicotinate Formula: C6H4NO2 Charge: -1 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item	pnc-1 | pnc-2	Nicotinate and nicotinamide metabolism
RC00102Name: NAD nucleosidase Type: Regular Location: Cytosol KEGG ID: R00102 click to see details on this item	3.5.1.-Name: nAD nucleosidase Other names: nAD-dependent histone deacetylase click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		adpribName: ADPribose Formula: C15H21N5O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item	sir-2.1 | sir-2.2 | sir-2.3 | sir-2.4	Nicotinate and nicotinamide metabolism
RC04176Name: NAD+:poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase (PARP) Type: Regular Location: Cytosol KEGG ID: R04176 click to see details on this item	2.4.2.30Name: NAD+ ADP-ribosyltransferase Other names: poly(ADP-ribose) synthase, ADP-ribosyltransferase (polymerizing), NAD ADP-ribosyltransferase, PARP, PARP-1, NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase (incorrect), NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase click to see details on this item	[c] : nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		polyadpribName: poly adp ribose Formula: C15H19N5O13P2 Charge: -2 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	parp-1 | parp-2 | tank-1	Nicotinate and nicotinamide metabolism
RC10633Name: NAD-dependent histone deacetylase Type: Regular Location: Cytosol KEGG ID: R10633 click to see details on this item	3.5.1.-Name: nAD nucleosidase Other names: nAD-dependent histone deacetylase click to see details on this item	[c] : nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + NaclysName: Histone N6-acetyl-L-lysine Formula: XC8H14N2O2 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item + NlysName: Histone-L-Lysine Formula: XC6H13N2O Charge: 1 click to see details on this item + ac_adpribName: O-Acetyl-ADP-ribose Formula: C17H23N5O15P2 Charge: -2 click to see details on this item	sir-2.1 | sir-2.2 | sir-2.3 | sir-2.4	Nicotinate and nicotinamide metabolism
RC01269Name: S-Adenosyl-L-methionine:nicotinamide N-methyltransferase Type: Regular Location: Cytosol KEGG ID: R01269 click to see details on this item	2.1.1.1Name: nicotinamide N-methyltransferase Other names: nicotinamide methyltransferase click to see details on this item	[c] : ametName: S-Adenosyl-L-methionine Formula: C15H23N6O5S Charge: 1 click to see details on this item + ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item		ahcysName: S-Adenosyl-L-homocysteine Formula: C14H20N6O5S Charge: 0 click to see details on this item + 1mncamName: 1-Methylnicotinamide Formula: C7H9N2O Charge: 1 click to see details on this item	anmt-1 | anmt-3	Nicotinate and nicotinamide metabolism
TCE0766Name: Nicotinamide transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item[e]		ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item[c]	Not determined	Transport
EX00153Name: Nicotinamide exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	ncamName: Nicotinamide Formula: C6H6N2O Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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