Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	hmgcoa
Name .....................................................	:	Hydroxymethylglutaryl-CoA, etc.(S)-3-Hydroxy-3-methylglutaryl-CoA, Hydroxymethylglutaroyl coenzyme A, HMG-CoA, 3-Hydroxy-3-methylglutaryl-CoA
Model ID .....................................................	:	C00356
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00356
Formula .....................................................	:	C27H39N7O20P3S
Charge .....................................................	:	-5
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	hmgcoa
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Ketone body metabolism (c,m), Leucine degradation (m), Mevalonate metabolism (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01360Name: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) Type: Regular Location: Mitochondria KEGG ID: R01360 click to see details on this item	4.1.3.4Name: hydroxymethylglutaryl-CoA lyase Other names: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase click to see details on this item	[m] : hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item	Y71G12B.10	Ketone body metabolism
RC01978Name: acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) Type: Regular Location: Cytosol KEGG ID: R01978 click to see details on this item	2.3.3.10Name: hydroxymethylglutaryl-CoA synthase Other names: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, acetoacetyl coenzyme A transacetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme click to see details on this item	[c] : aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item	hmgs-1	Ketone body metabolism
RC02082Name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Type: Regular Location: Cytosol KEGG ID: R02082 click to see details on this item	1.1.1.34Name: hydroxymethylglutaryl-CoA reductase (NADPH) Other names: hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), S-3-hydroxy-3-methylglutaryl-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA), 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-CoA reductase (NADPH2) click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + mev-RName: (R)-Mevalonate Formula: C6H11O4 Charge: -1 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	hmgr-1	Mevalonate metabolism
RM02085Name: (S)-3-Hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming) Type: Regular Location: Mitochondria KEGG ID: R02085 click to see details on this item	4.2.1.18Name: methylglutaconyl-CoA hydratase Other names: methylglutaconyl coenzyme A hydratase, 3-methylglutaconyl CoA hydratase, methylglutaconase, (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase click to see details on this item	[m] : 3mgcoaName: 3-Methylglutaconyl-CoA Formula: C27H37N7O19P3S Charge: -5 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item	ech-5	Leucine degradation
TCM1289Name: Hydroxymethylglutaryl-CoA transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item[c]		hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item[m]	Not determined	Transport

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