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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
FBAFlux Balance Analysis PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network
Enzyme Overview
Enzyme (?) Identification in Enzyme Commission (EC) numbering system. ..................................................... : 2.3.3.10
Name ..................................................... : Hydroxymethylglutaryl-CoA synthase, etc.(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, Beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, Acetoacetyl coenzyme A transacetase, Hydroxymethylglutaryl coenzyme A synthase, Hydroxymethylglutaryl coenzyme A-condensing enzyme
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. ..................................................... : K01641E2.3.3.10; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
Genes ..................................................... : hmgs-1
Localization ..................................................... : Cytosol
Other associations ..................................................... : See reaction table below.
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
RC01978Name: acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Type: Regular
Location: Cytosol
KEGG ID: R01978

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2.3.3.10Name: hydroxymethylglutaryl-CoA synthase
Other names: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, acetoacetyl coenzyme A transacetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme

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[c] : aacoaName: Acetoacetyl-CoA
Formula: C25H36N7O18P3S
Charge: -4




click to see details on this item + accoaName: Acetyl-CoA
Formula: C23H34N7O17P3S
Charge: -4




click to see details on this item + h2oName: H2O
Formula: H2O
Charge: 0




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coaName: Coenzyme A
Formula: C21H32N7O16P3S
Charge: -4




click to see details on this item + hName: H+
Formula: H
Charge: 1




click to see details on this item + hmgcoaName: Hydroxymethylglutaryl-CoA
Formula: C27H39N7O20P3S
Charge: -5




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hmgs-1
Ketone body metabolism
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