Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	acac
Name .....................................................	:	Acetoacetate, etc.3-Oxobutanoic acid, beta-Ketobutyric acid, Acetoacetic acid
Model ID .....................................................	:	C00164
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00164
Formula .....................................................	:	C4H5O3
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	acac
Other associations .....................................................	:	See reaction table below (8 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Represented in 4 maps... Ketone body metabolism (c,m) Leucine degradation (m) Propionate degradation (m) Tyrosine metabolism (c,m)   Go to map

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01357Name: Acetoacetate:CoA ligase (AMP-forming) Type: Regular Location: Cytosol KEGG ID: R01357 click to see details on this item	6.2.1.16Name: acetoacetate---CoA ligase Other names: acetoacetyl-CoA synthetase click to see details on this item	[c] : acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	sur-5	Ketone body metabolism
RM03225Name: (S)-3-Hydroxybutanoate:2-oxoglutarate oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03225 click to see details on this item	1.1.99.24Name: hydroxyacid-oxoacid transhydrogenase Other names: transhydrogenase, hydroxy acid-oxo acid click to see details on this item	[m] : S3hbName: (S)-3-Hydroxybutanoate Formula: C4H7O3 Charge: -1 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + 2hglutName: (S)-2-Hydroxyglutarate Formula: C5H6O5 Charge: -2 click to see details on this item	hphd-1	Ketone body metabolism
RM01360Name: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) Type: Regular Location: Mitochondria KEGG ID: R01360 click to see details on this item	4.1.3.4Name: hydroxymethylglutaryl-CoA lyase Other names: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase click to see details on this item	[m] : hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item	Y71G12B.10	Ketone body metabolism
RM00410Name: succinyl-CoA:acetoacetate CoA-transferase Type: Regular Location: Mitochondria KEGG ID: R00410 click to see details on this item	2.8.3.5Name: 3-oxoacid CoA-transferase Other names: 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, succinyl-CoA transferase click to see details on this item	[m] : acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + succoaName: Succinyl-CoA Formula: C25H35N7O19P3S Charge: -5 click to see details on this item		aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item	C05C10.3	Ketone body metabolism
RC01364Name: 4-fumarylacetoacetate fumarylhydrolase Type: Regular Location: Cytosol KEGG ID: R01364 click to see details on this item	3.7.1.2Name: fumarylacetoacetase Other names: beta-diketonase, fumarylacetoacetate hydrolase click to see details on this item	[c] : 4fumacacName: 4-Fumarylacetoacetate Formula: C8H6O6 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	fah-1	Tyrosine metabolism
TCE0706Name: Acetoacetate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item[e]		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item[c]	Not determined	Transport
TCM0072Name: Acetoacetate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item[c]		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item[m]	Not determined	Transport
EX00164Name: Acetoacetate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item[e]			Not applicable	Exchange with the environment

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