WormFlux: mechanistic analysis of C. elegans metabolism

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? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

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PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	aacoa
Name .....................................................	:	Acetoacetyl-CoA, etc.Acetoacetyl coenzyme A, 3-Acetoacetyl-CoA
Model ID .....................................................	:	C00332
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00332
Formula .....................................................	:	C25H36N7O18P3S
Charge .....................................................	:	-4
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	aacoa
Other associations .....................................................	:	See reaction table below (7 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Go to map

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01357Name: Acetoacetate:CoA ligase (AMP-forming) Type: Regular Location: Cytosol KEGG ID: R01357 click to see details on this item	6.2.1.16Name: acetoacetate---CoA ligase Other names: acetoacetyl-CoA synthetase click to see details on this item	[c] : acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	sur-5	Ketone body metabolism
RM00238Name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Type: Regular Location: Mitochondria KEGG ID: R00238 click to see details on this item	2.3.1.9Name: acetyl-CoA C-acetyltransferase Other names: acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, thiolase II click to see details on this item	[m] : (2) accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item	T02G5.7 \| kat-1	Ketone body metabolism
RM01975Name: (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R01975 click to see details on this item	1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[m] : aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		3hbcoaName: (S)-3-Hydroxybutanoyl-CoA Formula: C25H38N7O18P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	B0272.3 \| F54C8.1 \| ech-8	Ketone body metabolism
RC00238Name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Type: Regular Location: Cytosol KEGG ID: R00238 click to see details on this item	2.3.1.9Name: acetyl-CoA C-acetyltransferase Other names: acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, thiolase II click to see details on this item	[c] : (2) accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item	T02G5.7	Fatty acid biosynthesis
RC01975Name: (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01975 click to see details on this item	1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[c] : aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		3hbcoaName: (S)-3-Hydroxybutanoyl-CoA Formula: C25H38N7O18P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	F54C8.1 \| ech-8 \| ech-9 \| hacd-1	Ketone body metabolism
RM00410Name: succinyl-CoA:acetoacetate CoA-transferase Type: Regular Location: Mitochondria KEGG ID: R00410 click to see details on this item	2.8.3.5Name: 3-oxoacid CoA-transferase Other names: 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, succinyl-CoA transferase click to see details on this item	[m] : acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + succoaName: Succinyl-CoA Formula: C25H35N7O19P3S Charge: -5 click to see details on this item		aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item	C05C10.3	Ketone body metabolism
RC01978Name: acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) Type: Regular Location: Cytosol KEGG ID: R01978 click to see details on this item	2.3.3.10Name: hydroxymethylglutaryl-CoA synthase Other names: (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, acetoacetyl coenzyme A transacetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme click to see details on this item	[c] : aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + hmgcoaName: Hydroxymethylglutaryl-CoA Formula: C27H39N7O20P3S Charge: -5 click to see details on this item	hmgs-1	Ketone body metabolism

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