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E.g.
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trehalose?phosphatase
covers both
trehalose phosphatase
and
trehalose-phosphatase
, of which, only the latter fits the nomenclature used in this database.
*
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E.g.
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tre-*
brings all genes from trehalase family;
coenzyme*A
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coenzyme A
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, and
coenzymeA
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Network
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FBA
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lux
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alance
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nalysis
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athway
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nrichment
A
nalysis
WormClust
Clustering- and enrichment-based association of genes with the metabolic network
Enzyme Overview
Enzyme
(?)
Identification in
Enzyme Commission (EC)
numbering system.
.....................................................
:
1.1.1.34
Name
.....................................................
:
Hydroxymethylglutaryl-CoA reductase (NADPH),
etc.
Hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase, Beta-hydroxy-beta-methylglutaryl coenzyme A reductase, Hydroxymethylglutaryl CoA reductase (NADPH), S-3-hydroxy-3-methylglutaryl-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA), 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), Hydroxymethylglutaryl-CoA reductase (NADPH2)
KO
(?)
The
KEGG
orthology group (KO) that is associated with this enzyme.
.....................................................
:
K00021
HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Genes
.....................................................
:
hmgr-1
Localization
.....................................................
:
Cytosol
Other associations
.....................................................
:
See reaction table below
.
External links
KEGG
BRENDA
Reactions
ID
Enzyme
Reactants
Products
Genes
(?)
Multiple genes are separated by OR (
I
) or AND (
&
).
I
indicates that genes are
redundant
within the group (
e.g.
paralogs encoding the same enzyme).
&
indicates that genes are
non-redundant
within the group (
e.g.
genes encoding different subunits of the same enzyme).
If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs,
each group with multiple genes is shown in parentheses
.
Pathway
RC02082
Name:
(R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
Type:
Regular
Location:
Cytosol
KEGG ID:
R02082
click to see details on this item
1.1.1.34
Name:
hydroxymethylglutaryl-CoA reductase (NADPH)
Other names:
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), S-3-hydroxy-3-methylglutaryl-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA), 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-CoA reductase (NADPH2)
click to see details on this item
[c] : (2)
h
Name:
H+
Formula:
H
Charge:
1
click to see details on this item
+
hmgcoa
Name:
Hydroxymethylglutaryl-CoA
Formula:
C27H39N7O20P3S
Charge:
-5
click to see details on this item
+ (2)
nadph
Name:
Nicotinamide adenine dinucleotide phosphate - reduced
Formula:
C21H26N7O17P3
Charge:
-4
click to see details on this item
coa
Name:
Coenzyme A
Formula:
C21H32N7O16P3S
Charge:
-4
click to see details on this item
+
mev-R
Name:
(R)-Mevalonate
Formula:
C6H11O4
Charge:
-1
click to see details on this item
+ (2)
nadp
Name:
Nicotinamide adenine dinucleotide phosphate
Formula:
C21H25N7O17P3
Charge:
-3
click to see details on this item
hmgr-1
Mevalonate metabolism
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