Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	2.3.1.199
Name .....................................................	:	Very-long-chain 3-oxoacyl-CoA synthase, etc.Very-long-chain 3-ketoacyl-CoA synthase, Very-long-chain beta-ketoacyl-CoA synthase, Condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name)
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	Not determined
Genes .....................................................	:	elo-1, elo-2, elo-3, elo-4, elo-5, elo-6, elo-7, elo-8, elo-9
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below (8 reactions in total)

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0210Name: Octacosanoic acid synthesis Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : lgnccoaName: lignocericyl coenzyme A Formula: C45H78N7O17P3S Charge: -4 click to see details on this item + (2) malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (4) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + (6) hName: H+ Formula: H Charge: 1 click to see details on this item		fa28p0coaName: octacosanoyl-CoA Formula: C49H86N7O17P3S Charge: -4 click to see details on this item + (2) co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + (2) coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + (4) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	elo-1 & let-767 & hpo-8 & art-1	Ascaroside biosynthesis
RCC0063Name: long chain fatty acid elongation (Stearidonoyl-CoA to Icosatetraenoyl-CoA) Type: Regular Location: Cytosol KEGG ID: R10825;R10826;R10827;R10828 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : strdnccoaName: stearidonyl coenzyme A Formula: C39H58N7O17P3S Charge: -4 click to see details on this item + malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item		eicostetcoaName: eicosatetranoyl coenzyme A Formula: C41H62N7O17P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	(elo-1 | elo-2) & let-767 & hpo-8 & art-1	Fatty acid biosynthesis
RCC0064Name: long chain fatty acid elongation (Linolenoyl-CoA to Eicosatrienoyl-CoA) Type: Regular Location: Cytosol KEGG ID: R09419;R10826;R10827;R10828 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : lnlncgcoaName: gamma-linolenoyl-CoA Formula: C39H60N7O17P3S Charge: -4 click to see details on this item + malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item		dlnlcgcoaName: dihomo-gamma-linolenyl coenzyme A Formula: C41H64N7O17P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	(elo-1 | elo-2) & let-767 & hpo-8 & art-1	Fatty acid biosynthesis
RCC0070Name: long chain fatty acid elongation (Palmitoleyl-coA to Vaccenyl-coA) Type: Regular Location: Cytosol KEGG ID: R09419;R10826;R10827;R10828 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : fa16p1n7coaName: Palmitoleyl-coA Formula: C37H60N7O17P3S Charge: -4 click to see details on this item + malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item		vacccoaName: Vaccenyl coenzyme A Formula: C39H64N7O17P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	(elo-1 | elo-2 | elo-3 | elo-4 | elo-5 | elo-6 | elo-7 | elo-9) & let-767 & hpo-8 & art-1	Fatty acid biosynthesis
RC07758Name: very-long-chain 3-oxoacyl-CoA synthase Type: Regular Location: Cytosol KEGG ID: R07758 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item	[c] : malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + pmtcoaName: Palmitoyl-CoA (n-C16:0CoA) Formula: C37H62N7O17P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		3oodcoaName: 3-Oxooctadecanoyl-CoA Formula: C39H64N7O18P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	elo-1	Fatty acid biosynthesis
RCC0124Name: merged fatty acid elongation (C18 to C24) Type: Regular Location: Cytosol KEGG ID: R10825;R10826;R10827;R10828 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : (9) hName: H+ Formula: H Charge: 1 click to see details on this item + (3) malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (6) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + stcoaName: Stearoyl-CoA (n-C18:0CoA) Formula: C39H66N7O17P3S Charge: -4 click to see details on this item		(3) co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + (3) coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + (6) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + lgnccoaName: lignocericyl coenzyme A Formula: C45H78N7O17P3S Charge: -4 click to see details on this item	elo-1 & let-767 & hpo-8 & art-1	Fatty acid biosynthesis
RCC0072Name: long chain fatty acid elongation (C13:iso to C15:iso) Type: Regular Location: Cytosol KEGG ID: R09419;R10826;R10827;R10828 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : fa13p0isoName: Fatty acid (C13:iso) Formula: C13H25O2 Charge: -1 click to see details on this item + malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item		fa15p0isoName: Fatty acid (C15:iso) Formula: C15H29O2 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	elo-5 & let-767 & hpo-8 & art-1	Fatty acid biosynthesis
RCC0073Name: long chain fatty acid elongation (C15:iso to C17:iso) Type: Regular Location: Cytosol KEGG ID: R09419;R10826;R10827;R10828 click to see details on this item	2.3.1.199Name: very-long-chain 3-oxoacyl-CoA synthase Other names: very-long-chain 3-ketoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme, CUT1 (gene name), CER6 (gene name), FAE1 (gene name), KCS (gene name), ELO (gene name) click to see details on this item 1.1.1.330Name: very-long-chain 3-oxoacyl-CoA reductase Other names: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name) click to see details on this item 4.2.1.134Name: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase Other names: PHS1 (gene name), PAS2 (gene name) click to see details on this item 1.3.1.93Name: very-long-chain enoyl-CoA reductase Other names: TSC13 (gene name), CER10 (gene name) click to see details on this item	[c] : fa15p0isoName: Fatty acid (C15:iso) Formula: C15H29O2 Charge: -1 click to see details on this item + malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item		fa17p0isoName: Fatty acid (C17:iso) Formula: C17H33O2 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	(elo-5 | elo-6) & let-767 & hpo-8 & art-1	Fatty acid biosynthesis

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