WormFlux: mechanistic analysis of C. elegans metabolism

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Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	mal-L
Name .....................................................	:	L-Malate, etc.(S)-Malate, L-Apple acid, L-Malic acid, L-2-Hydroxybutanedioic acid, Malate, Malic acid
Model ID .....................................................	:	C00149
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00149
Formula .....................................................	:	C4H4O5
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	mal-L
Other associations .....................................................	:	See reaction table below (15 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Go to map

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01082Name: (S)-malate hydro-lyase (fumarate-forming) Type: Regular Location: Mitochondria KEGG ID: R01082 click to see details on this item	4.2.1.2Name: fumarate hydratase Other names: fumarase, L-malate hydro-lyase, (S)-malate hydro-lyase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	fum-1	TCA cycle
RM00342Name: (S)-malate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00342 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mdh-1 \| mdh-2	TCA cycle
RC00342Name: (S)-malate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00342 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[c] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mdh-1	TCA cycle
RC01082Name: (S)-malate hydro-lyase (fumarate-forming) (cytosolic) Type: Regular Location: Cytosol KEGG ID: R01082 click to see details on this item	4.2.1.2Name: fumarate hydratase Other names: fumarase, L-malate hydro-lyase, (S)-malate hydro-lyase click to see details on this item	[c] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	fum-1	TCA cycle
RM00472Name: malate synthase Type: Regular Location: Mitochondria KEGG ID: R00472 click to see details on this item	2.3.3.9Name: malate synthase Other names: L-malate glyoxylate-lyase (CoA-acetylating), glyoxylate transacetylase, glyoxylate transacetase, glyoxylic transacetase, malate condensing enzyme, malate synthetase, malic synthetase, malic-condensing enzyme click to see details on this item	[m] : accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + glxName: Glyoxylate Formula: C2H1O3 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item	icl-1	Glyoxylate and dicarboxylate metabolism
RM00216Name: (S)-Malate:NADP+ oxidoreductase(oxaloacetate-decarboxylating) Type: Regular Location: Mitochondria KEGG ID: R00216 click to see details on this item	1.1.1.40Name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Other names: 'malic' enzyme (ambiguous), pyruvic-malic carboxylase (ambiguous), malate dehydrogenase (decarboxylating, NADP+), NADP+-linked decarboxylating malic enzyme, NADP+-malic enzyme, NADP+-specific malic enzyme, NADP+-specific malate dehydrogenase, malate dehydrogenase (NADP+, decarboxylating), L-malate:NADP+ oxidoreductase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	men-1	Pyruvate metabolism
TCM1285Name: L-Malate and Citrate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[c] + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m]		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[m] + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c]	K11H3.3 \| Y37B11A.3	Transport
TCM0217Name: Sulfite and L-Malate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c] + so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item[m]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m] + so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0212Name: Thiosulfate and L-Malate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c] + tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item[m]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m] + tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCE1161Name: L-Malate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[e]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM1282Name: Phosphate and L-Malate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c] + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item[m]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m] + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0201Name: L-Malate and Sulfate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[m]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM1045Name: Succinate and L-Malate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c] + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item[m]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m] + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0109Name: 2-Oxoglutarate and L-Malate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item[m] + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c]		akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item[c] + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m]	Not determined	Transport
EX00149Name: L-Malate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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