Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	cit
Name .....................................................	:	Citrate, etc.Citric acid, 2-Hydroxy-1,2,3-propanetricarboxylic acid, 2-Hydroxytricarballylic acid
Model ID .....................................................	:	C00158
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00158
Formula .....................................................	:	C6H5O7
Charge .....................................................	:	-3
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	cit
Other associations .....................................................	:	See reaction table below (9 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Pyruvate metabolism (c,m), TCA cycle (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM00351Name: acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) Type: Regular Location: Mitochondria KEGG ID: R00351 click to see details on this item	2.3.3.1Name: citrate (Si)-synthase Other names: (R)-citric synthase, citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetyl-CoA] click to see details on this item	[m] : accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	cts-1	TCA cycle
RC00352Name: acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating] Type: Regular Location: Cytosol KEGG ID: R00352 click to see details on this item	2.3.3.8Name: ATP citrate synthase Other names: ATP-citric lyase, ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating), acetyl-CoA:oxaloacetate acetyltransferase (isomerizing, ADP-phosphorylating), adenosine triphosphate citrate lyase, citrate cleavage enzyme, citrate-ATP lyase, citric cleavage enzyme, ATP citrate (pro-S)-lyase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item	acly-2 | acly-1	TCA cycle
RCC0001Name: citrate hydro-lyase (cis-aconitate-forming) Type: Regular Location: Cytosol KEGG ID: R01325;R01900 click to see details on this item	4.2.1.3Name: aconitate hydratase Other names: cis-aconitase, aconitase, AcnB, 2-methylaconitate hydratase, citrate(isocitrate) hydro-lyase click to see details on this item	[c] : citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item		icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item	aco-1	TCA cycle
RMC0001Name: isocitrate hydro-lyase (cis-aconitate-forming) Type: Regular Location: Mitochondria KEGG ID: R01325;R01900 click to see details on this item	4.2.1.3Name: aconitate hydratase Other names: cis-aconitase, aconitase, AcnB, 2-methylaconitate hydratase, citrate(isocitrate) hydro-lyase click to see details on this item	[m] : citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item		icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item	aco-2	TCA cycle
TCM1285Name: L-Malate and Citrate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[c] + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m]		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[m] + mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c]	K11H3.3 | Y37B11A.3	Transport
TCM1277Name: Phosphoenolpyruvate and Citrate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[c] + pepName: Phosphoenolpyruvate Formula: C3H2O6P Charge: -3 click to see details on this item[m]		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[m] + pepName: Phosphoenolpyruvate Formula: C3H2O6P Charge: -3 click to see details on this item[c]	K11H3.3 | Y37B11A.3	Transport
TCE1154Name: Citrate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[e]		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[c]	Not determined	Transport
TCM1047Name: Isocitrate and Citrate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[c] + icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item[m]		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[m] + icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item[c]	Not determined	Transport
EX00158Name: Citrate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item[e]			Not applicable	Exchange with the environment

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