WormFlux: mechanistic analysis of C. elegans metabolism

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? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

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PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	so4
Name .....................................................	:	Sulfate, etc.Sulfuric acid
Model ID .....................................................	:	C00059
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00059
Formula .....................................................	:	O4S
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	so4
Other associations .....................................................	:	See reaction table below (13 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Purine metabolism (c,m), Sulfur metabolism (c,m)

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00529Name: ATP:sulfate adenylyltransferase Type: Regular Location: Cytosol KEGG ID: R00529 click to see details on this item	2.7.7.4Name: sulfate adenylyltransferase Other names: ATP-sulfurylase, adenosine-5'-triphosphate sulfurylase, adenosinetriphosphate sulfurylase, adenylylsulfate pyrophosphorylase, ATP sulfurylase, ATP-sulfurylase, sulfurylase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item		apsName: Adenosine 5'-phosphosulfate Formula: C10H12N5O10PS Charge: -2 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	pps-1	Purine metabolism
RC00507Name: 3'-phosphoadenylyl-sulfate sulfohydrolase Type: Regular Location: Cytosol KEGG ID: R00507 click to see details on this item	3.6.1.9Name: nucleotide diphosphatase Other names: nucleotide pyrophosphatase, nucleotide-sugar pyrophosphatase click to see details on this item	[c] : papsName: 3'-Phosphoadenylyl sulfate Formula: C10H11N5O13P2S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item + papName: "Adenosine 3',5'-bisphosphate" Formula: C10H11N5O10P2 Charge: -4 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item	C27A7.1 \| C27A7.3	Purine metabolism
RMC0054Name: Sulfite:ferricytochrome-c oxidoreductase Type: Regular Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	1.8.3.1Name: sulfite oxidase click to see details on this item	(2.0) ficytCName: Ferricytochrome c Formula: C42H42FeN8O8S2R4 Charge: 1 click to see details on this item[m] + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item[c] + so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item[c]		(2.0) focytCName: Ferrocytochrome C Formula: C42H42FeN8O8S2R4 Charge: 0 click to see details on this item[m] + (2.0) hName: H+ Formula: H Charge: 1 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	suox-1 & (cyc-2.1 \| cyc-2.2)	Sulfur metabolism
RM00533Name: Sulfite:oxygen oxidoreductase Type: Regular Location: Mitochondria, Cytosol KEGG ID: R00533 click to see details on this item	1.8.3.1Name: sulfite oxidase click to see details on this item	so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item[c] + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item[m] + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item[c]		so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c] + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item[m]	suox-1	Sulfur metabolism
RM10151Name: Thiosulfate oxidation (cytochrome c reducing) Type: Regular Location: Mitochondria KEGG ID: R10151 click to see details on this item	Not applicable	[m] : tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item + (5.0) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + (8.0) ficytCName: Ferricytochrome c Formula: C42H42FeN8O8S2R4 Charge: 1 click to see details on this item		(2.0) so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item + (8.0) focytCName: Ferrocytochrome C Formula: C42H42FeN8O8S2R4 Charge: 0 click to see details on this item + (10.0) hName: H+ Formula: H Charge: 1 click to see details on this item	cyc-2.1 \| cyc-2.2	Sulfur metabolism
TCE5341Name: Quinolinate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	qulnName: Quinolinate Formula: C7H3NO4 Charge: -2 click to see details on this item[e] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]		qulnName: Quinolinate Formula: C7H3NO4 Charge: -2 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[e]	Not determined	Transport
TCE0611Name: Sulfate and Chloride transport Type: Transport Location: Extracellular, Cytosol KEGG ID: NA click to see details on this item	Not applicable	clName: Chloride Formula: Cl Charge: -1 click to see details on this item[c] + (2.0) so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[e]		clName: Chloride Formula: Cl Charge: -1 click to see details on this item[e] + (2.0) so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCE0486Name: Sodium and Sulfate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	(2.0) na1Name: Sodium Formula: Na Charge: 1 click to see details on this item[e] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[e]		(2.0) na1Name: Sodium Formula: Na Charge: 1 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCE1127Name: Sulfate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[e]		so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0201Name: L-Malate and Sulfate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[m]		mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item[m] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0181Name: Fumarate and Sulfate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[m]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[m] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCE0622Name: Sodium and Sulfate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	(3.0) na1Name: Sodium Formula: Na Charge: 1 click to see details on this item[e] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[e]		(3.0) na1Name: Sodium Formula: Na Charge: 1 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
EX00059Name: Sulfate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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