WormFlux: mechanistic analysis of C. elegans metabolism

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? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

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PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	fum
Name .....................................................	:	Fumarate, etc.Fumaric acid, trans-Butenedioic acid
Model ID .....................................................	:	C00122
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00122
Formula .....................................................	:	C4H2O4
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	fum
Other associations .....................................................	:	See reaction table below (15 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Go to map

iCEL1314

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ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM02164Name: Succinate:ubiquinone oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R02164 click to see details on this item	1.3.5.1Name: succinate dehydrogenase (quinone) Other names: succinate dehydrogenase (ubiquinone), succinic dehydrogenase, complex II (ambiguous), succinate dehydrogenase complex, SDH, succinate:ubiquinone oxidoreductase click to see details on this item	[m] : qName: Ubiquinone Formula: C14H18O4 Charge: 0 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item		qh2Name: Ubiquinol Formula: C14H20O4 Charge: 0 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item	[(sdha-1 \| sdha-2) & sdhb-1] & mev-1 & sdhd-1	Electron transport chain
RM01082Name: (S)-malate hydro-lyase (fumarate-forming) Type: Regular Location: Mitochondria KEGG ID: R01082 click to see details on this item	4.2.1.2Name: fumarate hydratase Other names: fumarase, L-malate hydro-lyase, (S)-malate hydro-lyase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	fum-1	TCA cycle
RMC0183Name: fumarate reductase Type: Regular Location: Mitochondria KEGG ID: R02164 click to see details on this item	1.3.5.4Name: fumarate reductase (quinol) Other names: FRD, menaquinol-fumarate oxidoreductase, succinate dehydrogenase (menaquinone), succinate:menaquinone oxidoreductase, fumarate reductase (menaquinone), complex II (ambiguous) click to see details on this item	[m] : rq9h2Name: Rhodoquinonol-9 Formula: C53H83NO3 Charge: 0 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item		rq9Name: Rhodoquinone-9 Formula: C53H81NO3 Charge: 0 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item	F48E8.3	TCA cycle
RC01082Name: (S)-malate hydro-lyase (fumarate-forming) (cytosolic) Type: Regular Location: Cytosol KEGG ID: R01082 click to see details on this item	4.2.1.2Name: fumarate hydratase Other names: fumarase, L-malate hydro-lyase, (S)-malate hydro-lyase click to see details on this item	[c] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	fum-1	TCA cycle
RC01083Name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Type: Regular Location: Cytosol KEGG ID: R01083 click to see details on this item	4.3.2.2Name: adenylosuccinate lyase Other names: adenylosuccinase, succino AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) click to see details on this item	[c] : dcampName: "N6-(1,2-Dicarboxyethyl)-AMP" Formula: C14H14N5O11P Charge: -4 click to see details on this item		ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item	adsl-1	Aspartate and asparagine metabolism
RC04559Name: 1-(5-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase Type: Regular Location: Cytosol KEGG ID: R04559 click to see details on this item	4.3.2.2Name: adenylosuccinate lyase Other names: adenylosuccinase, succino AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) click to see details on this item	[c] : 25aicsName: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate Formula: C13H15N4O12P Charge: -4 click to see details on this item		aicarName: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide Formula: C9H13N4O8P Charge: -2 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item	adsl-1	Purine metabolism
RC01364Name: 4-fumarylacetoacetate fumarylhydrolase Type: Regular Location: Cytosol KEGG ID: R01364 click to see details on this item	3.7.1.2Name: fumarylacetoacetase Other names: beta-diketonase, fumarylacetoacetate hydrolase click to see details on this item	[c] : 4fumacacName: 4-Fumarylacetoacetate Formula: C8H6O6 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		acacName: Acetoacetate Formula: C4H5O3 Charge: -1 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	fah-1	Tyrosine metabolism
TCE1186Name: Fumarate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[e]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0118Name: Thiosulfate and Fumarate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c] + tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item[m]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[m] + tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0207Name: Phosphate and Fumarate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c] + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item[m]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[m] + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0139Name: Sulfite and Fumarate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c] + so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item[m]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[m] + so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM0181Name: Fumarate and Sulfate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[m]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[m] + so4Name: Sulfate Formula: O4S Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM1071Name: Mixed transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fadh2Name: Flavin adenine dinucleotide reduced Formula: C27H33N9O15P2 Charge: -2 click to see details on this item[m] + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c]		fadName: Flavin adenine dinucleotide oxidized Formula: C27H31N9O15P2 Charge: -2 click to see details on this item[m] + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM1043Name: Succinate and Fumarate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[m] + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item[c]		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[c] + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item[m]	Not determined	Transport
EX00122Name: Fumarate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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