WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.1.1.37
Name .....................................................	:	Malate dehydrogenase, etc.Malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, Malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, Malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00026MDH2; malate dehydrogenase [EC:1.1.1.37], K00025MDH1; malate dehydrogenase [EC:1.1.1.37]
Genes .....................................................	:	mdh-1, mdh-2
Localization .....................................................	:	Cytosol, Mitochondria
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM00342Name: (S)-malate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00342 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mdh-1 \| mdh-2	TCA cycle
RC00342Name: (S)-malate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00342 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[c] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mdh-1	TCA cycle
RM07136Name: L-sulfolactate dehydrogenase Type: Regular Location: Mitochondria KEGG ID: R07136 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[m] : nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + sl-LName: L-sulfolactate Formula: C3H4O6S Charge: -2 click to see details on this item		3spyrName: 3-Sulfopyruvate Formula: C3H2O6S Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	mdh-1 \| mdh-2	Cysteine metabolism

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