WormFlux: mechanistic analysis of C. elegans metabolism

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Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	glyc3p
Name .....................................................	:	Glycerol 3-phosphate, etc.sn-Glycerol 3-phosphate, Glycerophosphoric acid, D-Glycerol 1-phosphate
Model ID .....................................................	:	C00093
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00093
Formula .....................................................	:	C3H7O6P
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	glyc3p
Other associations .....................................................	:	See reaction table below (13 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Glycerolipid metabolism (c), Glycerophospholipid metabolism (c,m)

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00851Name: acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase (acting on Rtotal group) Type: Regular Location: Cytosol KEGG ID: R00851 click to see details on this item	2.3.1.15Name: glycerol-3-phosphate 1-O-acyltransferase Other names: alpha-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous) click to see details on this item	[c] : RtotalcoaName: R total Coenzyme A Formula: CO2FULLRC21H31N7O15P3S Charge: -4 click to see details on this item + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item		alpa_plName: Lysophosphatidic acid (phospholipids) Formula: C3H6O5PFULLRCO2 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item	acl-6 \| (acl-4 \| acl-5)	Glycerophospholipid metabolism
RC00847Name: ATP:glycerol 3-phosphotransferase Type: Regular Location: Cytosol KEGG ID: R00847 click to see details on this item	2.7.1.30Name: glycerol kinase Other names: glycerokinase, GK, ATP:glycerol-3-phosphotransferase, glycerol kinase (phosphorylating), glyceric kinase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + glycName: Glycerol Formula: C3H8O3 Charge: 0 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	R11F4.1	Glycerolipid metabolism
RCC0079Name: acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase (acting on Rtotal4 group) Type: Regular Location: Cytosol KEGG ID: R00851 click to see details on this item	2.3.1.15Name: glycerol-3-phosphate 1-O-acyltransferase Other names: alpha-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous) click to see details on this item	[c] : Rtotal4coaName: R total 4 coenzyme A Formula: CO2FULLR4C21H31N7O15P3S Charge: -4 click to see details on this item + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item		alpa_tagName: Lysophosphatidic acid (TAG) Formula: C3H6O5PFULLR4CO2 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item	acl-6 \| (acl-4 \| acl-5)	Glycerolipid metabolism
RC00842Name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00842 click to see details on this item	1.1.1.8Name: glycerol-3-phosphate dehydrogenase (NAD+) Other names: alpha-glycerol phosphate dehydrogenase (NAD+), alpha-glycerophosphate dehydrogenase (NAD+), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD+), glycerophosphate dehydrogenase (NAD+), hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase (ambiguous), NAD+-alpha-glycerophosphate dehydrogenase, NAD+-dependent glycerol phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-L-glycerol-3-phosphate dehydrogenase, NAD+-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, glycerol-3-phosphate dehydrogenase (NAD+), L-glycerol-3-phosphate dehydrogenase (ambiguous) click to see details on this item	[c] : dhapName: Dihydroxyacetone phosphate Formula: C3H5O6P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	gpdh-1	Glycerophospholipid metabolism
RM00842Name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00842 click to see details on this item	1.1.1.8Name: glycerol-3-phosphate dehydrogenase (NAD+) Other names: alpha-glycerol phosphate dehydrogenase (NAD+), alpha-glycerophosphate dehydrogenase (NAD+), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD+), glycerophosphate dehydrogenase (NAD+), hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase (ambiguous), NAD+-alpha-glycerophosphate dehydrogenase, NAD+-dependent glycerol phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-L-glycerol-3-phosphate dehydrogenase, NAD+-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, glycerol-3-phosphate dehydrogenase (NAD+), L-glycerol-3-phosphate dehydrogenase (ambiguous) click to see details on this item	[m] : dhapName: Dihydroxyacetone phosphate Formula: C3H5O6P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	gpdh-2	Glycerophospholipid metabolism
RC01030Name: sn-Glycero-3-phosphocholine glycerophosphohydrolase Type: Regular Location: Cytosol KEGG ID: R01030 click to see details on this item	3.1.4.46Name: glycerophosphodiester phosphodiesterase Other names: gene hpd protein, glycerophosphoryl diester phosphodiesterase, IgD-binding protein D click to see details on this item	[c] : g3pcName: sn-Glycero-3-phosphocholine Formula: C8H20NO6P Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		cholName: Choline Formula: C5H14NO Charge: 1 click to see details on this item + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	T12B3.3 \| T22G5.1 \| ZC155.4	Glycerophospholipid metabolism
RC01470Name: sn-Glycero-3-phosphoethanolamine glycerophosphohydrolase Type: Regular Location: Cytosol KEGG ID: R01470 click to see details on this item	3.1.4.46Name: glycerophosphodiester phosphodiesterase Other names: gene hpd protein, glycerophosphoryl diester phosphodiesterase, IgD-binding protein D click to see details on this item	[c] : g3peName: sn-Glycero-3-phosphoethanolamine Formula: C5H14NO6P Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ethaName: Ethanolamine Formula: C2H8NO Charge: 1 click to see details on this item + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	T12B3.3 \| T22G5.1 \| ZC155.4	Glycerophospholipid metabolism
RC01801Name: CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase Type: Regular Location: Cytosol KEGG ID: R01801 click to see details on this item	2.7.8.5Name: CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase Other names: glycerophosphate phosphatidyltransferase, 3-phosphatidyl-1'-glycerol-3'-phosphate synthase, CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase, phosphatidylglycerophosphate synthase, phosphatidylglycerolphosphate synthase, PGP synthase, CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase, CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase, glycerol phosphate phosphatidyltransferase, glycerol 3-phosphate phosphatidyltransferase, phosphatidylglycerol phosphate synthase, phosphatidylglycerol phosphate synthetase, phosphatidylglycerophosphate synthetase, sn-glycerol-3-phosphate phosphatidyltransferase click to see details on this item	[c] : cdpdagName: CDP diacylglycerol Formula: C12H17N3O11P2FULLRCO2FULLR2CO2 Charge: -2 click to see details on this item + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item		cmpName: CMP Formula: C9H12N3O8P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + pgpName: phosphatidyl glycerol phosphate Formula: C6H11O9P2FULLRCO2FULLR2CO2 Charge: -3 click to see details on this item	pgs-1	Glycerophospholipid metabolism
RM08657Name: sn-glycerol 3-phosphate:quinone oxidoreductase Type: Regular Location: Cytosol, Mitochondria KEGG ID: R08657 click to see details on this item	1.1.5.3Name: glycerol-3-phosphate dehydrogenase Other names: alpha-glycerophosphate dehydrogenase, alpha-glycerophosphate dehydrogenase (acceptor), anaerobic glycerol-3-phosphate dehydrogenase, DL-glycerol 3-phosphate oxidase (misleading), FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-dependent sn-glycerol-3-phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol 3-phosphate dehydrogenase, FAD-linked L-glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate dehydrogenase, flavoprotein-linked L-glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate cytochrome c reductase (misleading), glycerol phosphate dehydrogenase, glycerol phosphate dehydrogenase (acceptor), glycerol phosphate dehydrogenase (FAD), glycerol-3-phosphate CoQ reductase, glycerol-3-phosphate dehydrogenase (flavin-linked), glycerol-3-phosphate:CoQ reductase, glycerophosphate dehydrogenase, L-3-glycerophosphate-ubiquinone oxidoreductase, L-glycerol-3-phosphate dehydrogenase (ambiguous), L-glycerophosphate dehydrogenase, mGPD, mitochondrial glycerol phosphate dehydrogenase, NAD+-independent glycerol phosphate dehydrogenase, pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase, sn-glycerol 3-phosphate oxidase (misleading), sn-glycerol-3-phosphate dehydrogenase, sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase, sn-glycerol-3-phosphate:acceptor 2-oxidoreductase click to see details on this item	qName: Ubiquinone Formula: C14H18O4 Charge: 0 click to see details on this item[m] + glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item[c]		dhapName: Dihydroxyacetone phosphate Formula: C3H5O6P Charge: -2 click to see details on this item[c] + qh2Name: Ubiquinol Formula: C14H20O4 Charge: 0 click to see details on this item[m]	T25G3.4 \| Y50E8A.6	Glycerophospholipid metabolism
DGR0021Name: Bacterial phosphatidylglycerol degradation Type: Degradation Location: Cytosol KEGG ID: NA click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : pg_BACName: Phosphatidylglycerol (bacteria) Formula: C8H12O10PR2 Charge: -1 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + glycName: Glycerol Formula: C3H8O3 Charge: 0 click to see details on this item + (2) Rtotal_BACName: R total from bacterial diet Formula: RCO2 Charge: -1 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Bacterial digestion
TCE5337Name: Glycerol 3-phosphate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item[e]		glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item[c]	Not determined	Transport
TCM1288Name: Glycerol 3-phosphate transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item[c]		glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item[m]	Not determined	Transport
EX00093Name: Glycerol 3-phosphate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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