Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	cholcoa
Name .....................................................	:	Choloyl-CoA, etc.3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanoyl-CoA, 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-one-CoA
Model ID .....................................................	:	C01794
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C01794
Formula .....................................................	:	C45H70N7O20P3S
Charge .....................................................	:	-4
Localization .....................................................	:	Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	cholcoa
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Biosynthesis of bile acid-like molecules (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC03719Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase Type: Regular Location: Cytosol KEGG ID: R03719 click to see details on this item	2.3.1.176Name: propanoyl-CoA C-acyltransferase Other names: peroxisomal thiolase 2, sterol carrier protein-chi, SCPchi, PTE-2 (ambiguous) click to see details on this item	[c] : cholcoaoneName: "3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA" Formula: C48H74N7O21P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		cholcoaName: Choloyl-CoA Formula: C45H70N7O20P3S Charge: -4 click to see details on this item + ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item	(daf-22 | nlt-1)	Biosynthesis of bile acid-like molecules
RC07296Name: choloyl-CoA hydrolase Type: Regular Location: Cytosol KEGG ID: R07296 click to see details on this item	3.1.2.27Name: choloyl-CoA hydrolase Other names: PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, peroxisomal acyl-CoA thioesterase 2 click to see details on this item	[c] : cholcoaName: Choloyl-CoA Formula: C45H70N7O20P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		cholateName: Cholate Formula: C24H39O5 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	F25E2.3	Biosynthesis of bile acid-like molecules
RC03718Name: Choloyl-CoA:glycine N-choloyltransferase Type: Regular Location: Cytosol KEGG ID: R03718 click to see details on this item	2.3.1.65Name: bile acid-CoA:amino acid N-acyltransferase Other names: glycine---taurine N-acyltransferase, amino acid N-choloyltransferase, BAT, glycine N-choloyltransferase, BACAT, cholyl-CoA glycine-taurine N-acyltransferase, cholyl-CoA:taurine N-acyltransferase click to see details on this item	[c] : cholcoaName: Choloyl-CoA Formula: C45H70N7O20P3S Charge: -4 click to see details on this item + glyName: Glycine Formula: C2H5NO2 Charge: 0 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + gcholaName: glycocholate Formula: C26H43NO6 Charge: 0 click to see details on this item	C31H5.6 | W03D8.8 | T05E7.1 | K05B2.4	Biosynthesis of bile acid-like molecules
RC03720Name: Choloyl-CoA:taurine N-choloyltransferase Type: Regular Location: Cytosol KEGG ID: R03720 click to see details on this item	2.3.1.65Name: bile acid-CoA:amino acid N-acyltransferase Other names: glycine---taurine N-acyltransferase, amino acid N-choloyltransferase, BAT, glycine N-choloyltransferase, BACAT, cholyl-CoA glycine-taurine N-acyltransferase, cholyl-CoA:taurine N-acyltransferase click to see details on this item	[c] : cholcoaName: Choloyl-CoA Formula: C45H70N7O20P3S Charge: -4 click to see details on this item + taurName: Taurine Formula: C2H7NO3S Charge: 0 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + tcholaName: taurocholic acid Formula: C26H45NO7S Charge: 0 click to see details on this item	C31H5.6 | W03D8.8 | T05E7.1 | K05B2.4	Biosynthesis of bile acid-like molecules

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