WormFlux: mechanistic analysis of C. elegans metabolism

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Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	cholcoaone
Name .....................................................	:	"3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA", etc.3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA, 3alpha,7alpha,12alpha-Trihydroxy-24-oxo-5beta-cholestanoyl-CoA
Model ID .....................................................	:	C05467
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C05467
Formula .....................................................	:	C48H74N7O21P3S
Charge .....................................................	:	-4
Localization .....................................................	:	Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	cholcoaone
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Biosynthesis of bile acid-like molecules (c)

iCEL1314

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Enzyme

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Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0050Name: D-bifunctional protein Type: Regular Location: Cytosol KEGG ID: R04813;R04812 click to see details on this item	4.2.1.107Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase Other names: 46 kDa hydratase 2, (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase click to see details on this item 1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[c] : cholcoadsName: "3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA" Formula: C48H74N7O20P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		cholcoaoneName: "3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA" Formula: C48H74N7O21P3S Charge: -4 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	dhs-25 \| dhs-28 \| maoc-1	Biosynthesis of bile acid-like molecules
RC03719Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase Type: Regular Location: Cytosol KEGG ID: R03719 click to see details on this item	2.3.1.176Name: propanoyl-CoA C-acyltransferase Other names: peroxisomal thiolase 2, sterol carrier protein-chi, SCPchi, PTE-2 (ambiguous) click to see details on this item	[c] : cholcoaoneName: "3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA" Formula: C48H74N7O21P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		cholcoaName: Choloyl-CoA Formula: C45H70N7O20P3S Charge: -4 click to see details on this item + ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item	(daf-22 \| nlt-1)	Biosynthesis of bile acid-like molecules

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