Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	3hbcoa
Name .....................................................	:	(S)-3-Hydroxybutanoyl-CoA, etc.(S)-3-Hydroxybutyryl-CoA
Model ID .....................................................	:	C01144
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C01144
Formula .....................................................	:	C25H38N7O18P3S
Charge .....................................................	:	-4
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	3hbcoa
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Ketone body metabolism (c,m), Lysine degradation (m), Mitochondrial fatty acid degradation (m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0134Name: (S) 3-hydroxybutyryl-CoA hydrolase Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	3.1.2.4Name: 3-hydroxyisobutyryl-CoA hydrolase Other names: 3-hydroxy-isobutyryl CoA hydrolase, HIB CoA deacylase click to see details on this item	[c] : 3hbcoaName: (S)-3-Hydroxybutanoyl-CoA Formula: C25H38N7O18P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		S3hbName: (S)-3-Hydroxybutanoate Formula: C4H7O3 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	hach-1	Ketone body metabolism
RM03026Name: (S)-3-Hydroxybutanoyl-CoA hydro-lyase Type: Regular Location: Mitochondria KEGG ID: R03026 click to see details on this item	4.2.1.17Name: enoyl-CoA hydratase Other names: enoyl hydrase, unsaturated acyl-CoA hydratase, beta-hydroxyacyl-CoA dehydrase, beta-hydroxyacid dehydrase, hydratase, enoyl coenzyme A, acyl coenzyme A hydrase, crotonase, crotonyl hydrase, 2-octenoyl coenzyme A hydrase, enoyl coenzyme A hydratase, 2-enoyl-CoA hydratase, short-chain enoyl-CoA hydratase, ECH, trans-2-enoyl-CoA hydratase, enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), short chain enoyl coenzyme A hydratase, D-3-hydroxyacyl-CoA dehydratase, enol-CoA hydratase click to see details on this item	[m] : 3hbcoaName: (S)-3-Hydroxybutanoyl-CoA Formula: C25H38N7O18P3S Charge: -4 click to see details on this item		b2coaName: Crotonoyl-CoA Formula: C25H36N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	(ech-6 | ech-7) | (ech-1.2 | ech-1.1) | ech-3	Ketone body metabolism
RM01975Name: (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R01975 click to see details on this item	1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[m] : aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		3hbcoaName: (S)-3-Hydroxybutanoyl-CoA Formula: C25H38N7O18P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	B0272.3 | F54C8.1 | ech-8	Ketone body metabolism
RC01975Name: (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01975 click to see details on this item	1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[c] : aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		3hbcoaName: (S)-3-Hydroxybutanoyl-CoA Formula: C25H38N7O18P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	F54C8.1 | ech-8 | ech-9 | hacd-1	Ketone body metabolism

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