Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Pathway Overview

Name .....................................................	:	Folate biosynthesis
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	13
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	Folate biosynthesis

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00424Name: GTP cyclohydrolase I Type: Regular Location: Cytosol KEGG ID: R00428;R04639;R05046;R05048 click to see details on this item	3.5.4.16Name: GTP cyclohydrolase I Other names: GTP cyclohydrolase, guanosine triphosphate cyclohydrolase, guanosine triphosphate 8-deformylase, dihydroneopterin triphosphate synthase, GTP 8-formylhydrolase click to see details on this item	[c] : gtpName: GTP Formula: C10H12N5O14P3 Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ahdtName: "2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate" Formula: C9H12N5O13P3 Charge: -4 click to see details on this item + forName: Formate Formula: CH1O2 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	cat-4	Folate biosynthesis
RC04286Name: 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate lyase Type: Regular Location: Cytosol KEGG ID: R04286 click to see details on this item	4.2.3.12Name: 6-pyruvoyltetrahydropterin synthase Other names: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase, 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming) click to see details on this item	[c] : ahdtName: "2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate" Formula: C9H12N5O13P3 Charge: -4 click to see details on this item		6pthpName: "6-Pyruvoyl-5,6,7,8-tetrahydropterin" Formula: C9H11N5O3 Charge: 0 click to see details on this item + pppiName: Inorganic triphosphate Formula: HO10P3 Charge: -4 click to see details on this item	ptps-1	Folate biosynthesis
RC01793Name: 5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01793 click to see details on this item	1.5.1.34Name: 6,7-dihydropteridine reductase Other names: 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase click to see details on this item	[c] : dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item	qdpr-1	Folate biosynthesis
RC01794Name: 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01794 click to see details on this item	1.5.1.34Name: 6,7-dihydropteridine reductase Other names: 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase click to see details on this item	[c] : dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item	qdpr-1	Folate biosynthesis
RC04620Name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Type: Regular Location: Cytosol KEGG ID: R04620 click to see details on this item	3.1.3.1Name: alkaline phosphatase Other names: alkaline phosphomonoesterase, phosphomonoesterase, glycerophosphatase, alkaline phosphohydrolase, alkaline phenyl phosphatase, orthophosphoric-monoester phosphohydrolase (alkaline optimum) click to see details on this item	[c] : ahdtName: "2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate" Formula: C9H12N5O13P3 Charge: -4 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		dhnptName: Dihydroneopterin Formula: C9H13N5O4 Charge: 0 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + (3) piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	Y105C5B.3	Folate biosynthesis
RCC0157Name: sepiapterin reductase Type: Regular Location: Cytosol KEGG ID: R04285;R01813 click to see details on this item	1.1.1.153Name: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) Other names: SR click to see details on this item	[c] : 6pthpName: "6-Pyruvoyl-5,6,7,8-tetrahydropterin" Formula: C9H11N5O3 Charge: 0 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + (2) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(2) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item	Unknown	Folate biosynthesis
RC07212Name: L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (4a-Hydroxytetrahydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R07212 click to see details on this item	1.14.16.2Name: tyrosine 3-monooxygenase Other names: L-tyrosine hydroxylase, tyrosine 3-hydroxylase, tyrosine hydroxylase click to see details on this item	[c] : tyr-LName: L-Tyrosine Formula: C9H11NO3 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		34dhpheName: "3,4-Dihydroxy-L-phenylalanine" Formula: C9H11NO4 Charge: 0 click to see details on this item + thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine Formula: C9H15N5O4 Charge: 0 click to see details on this item	cat-2	Folate biosynthesis
RC01795Name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Type: Regular Location: Cytosol KEGG ID: R01795 click to see details on this item	1.14.16.1Name: phenylalanine 4-monooxygenase Other names: phenylalaninase, phenylalanine 4-hydroxylase, phenylalanine hydroxylase click to see details on this item	[c] : o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + phe-LName: L-Phenylalanine Formula: C9H11NO2 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item		dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + tyr-LName: L-Tyrosine Formula: C9H11NO3 Charge: 0 click to see details on this item	pah-1	Folate biosynthesis
RC07211Name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) (First step) Type: Regular Location: Cytosol KEGG ID: R07211 click to see details on this item	1.14.16.1Name: phenylalanine 4-monooxygenase Other names: phenylalaninase, phenylalanine 4-hydroxylase, phenylalanine hydroxylase click to see details on this item	[c] : o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + phe-LName: L-Phenylalanine Formula: C9H11NO2 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item		thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine Formula: C9H15N5O4 Charge: 0 click to see details on this item + tyr-LName: L-Tyrosine Formula: C9H11NO3 Charge: 0 click to see details on this item	pah-1	Folate biosynthesis
RC04734Name: 4a-hydroxytetrahydrobiopterin hydro-lyase Type: Regular Location: Cytosol KEGG ID: R04734 click to see details on this item	4.2.1.96Name: 4a-hydroxytetrahydrobiopterin dehydratase Other names: 4alpha-hydroxy-tetrahydropterin dehydratase, pterin-4alpha-carbinolamine dehydratase, 4a-hydroxytetrahydrobiopterin hydro-lyase click to see details on this item	[c] : thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine Formula: C9H15N5O4 Charge: 0 click to see details on this item		dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	pcbd-1	Folate biosynthesis
RC01814Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (Dihydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R01814 click to see details on this item	1.14.16.4Name: tryptophan 5-monooxygenase Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	tph-1	Folate biosynthesis
RC07213Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (4a-Hydroxytetrahydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R07213 click to see details on this item	1.14.16.4Name: tryptophan 5-monooxygenase Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase click to see details on this item	[c] : trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine Formula: C9H15N5O4 Charge: 0 click to see details on this item	tph-1	Folate biosynthesis
RC01815Name: L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (Dihydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R01815 click to see details on this item	1.14.16.2Name: tyrosine 3-monooxygenase Other names: L-tyrosine hydroxylase, tyrosine 3-hydroxylase, tyrosine hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + tyr-LName: L-Tyrosine Formula: C9H11NO3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		34dhpheName: "3,4-Dihydroxy-L-phenylalanine" Formula: C9H11NO4 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	cat-2	Folate biosynthesis

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