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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal
Enzyme Overview
Enzyme (?) Identification in Enzyme Commission (EC) numbering system. ..................................................... : 1.14.16.4
Name ..................................................... : Tryptophan 5-monooxygenase, etc.L-tryptophan hydroxylase, Indoleacetic acid-5-hydroxylase, Tryptophan 5-hydroxylase, Tryptophan hydroxylase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. ..................................................... : K00502TPH1_2; tryptophan 5-monooxygenase [EC:1.14.16.4]
Genes ..................................................... : tph-1
Localization ..................................................... : Cytosol
Other associations ..................................................... : See reaction table below.
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
RC01814Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (Dihydrobiopterin forming)
Type: Regular
Location: Cytosol
KEGG ID: R01814

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1.14.16.4Name: tryptophan 5-monooxygenase
Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase

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[c] : thbptName: Tetrahydrobiopterin
Formula: C9H15N5O3
Charge: 0




click to see details on this item + trp-LName: L-Tryptophan
Formula: C11H12N2O2
Charge: 0




click to see details on this item + o2Name: O2
Formula: O2
Charge: 0




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5htrpName: 5-Hydroxy-L-tryptophan
Formula: C11H12N2O3
Charge: 0




click to see details on this item + dhbptName: "6,7-Dihydrobiopterin"
Formula: C9H13N5O3
Charge: 0




click to see details on this item + h2oName: H2O
Formula: H2O
Charge: 0




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tph-1
Folate biosynthesis
RC07213Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (4a-Hydroxytetrahydrobiopterin forming)
Type: Regular
Location: Cytosol
KEGG ID: R07213

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1.14.16.4Name: tryptophan 5-monooxygenase
Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase

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[c] : trp-LName: L-Tryptophan
Formula: C11H12N2O2
Charge: 0




click to see details on this item + thbptName: Tetrahydrobiopterin
Formula: C9H15N5O3
Charge: 0




click to see details on this item + o2Name: O2
Formula: O2
Charge: 0




click to see details on this item
5htrpName: 5-Hydroxy-L-tryptophan
Formula: C11H12N2O3
Charge: 0




click to see details on this item + thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine
Formula: C9H15N5O4
Charge: 0




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tph-1
Folate biosynthesis
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