Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	5htrp
Name .....................................................	:	5-Hydroxy-L-tryptophan, etc.Oxitriptan
Model ID .....................................................	:	C00643
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00643
Formula .....................................................	:	C11H12N2O3
Charge .....................................................	:	0
Localization .....................................................	:	Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	5htrp
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate biosynthesis (c), Tryptophan degradation (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01814Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (Dihydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R01814 click to see details on this item	1.14.16.4Name: tryptophan 5-monooxygenase Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase click to see details on this item	[c] : thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + dhbptName: "6,7-Dihydrobiopterin" Formula: C9H13N5O3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	tph-1	Folate biosynthesis
RC07213Name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (4a-Hydroxytetrahydrobiopterin forming) Type: Regular Location: Cytosol KEGG ID: R07213 click to see details on this item	1.14.16.4Name: tryptophan 5-monooxygenase Other names: L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-hydroxylase, tryptophan hydroxylase click to see details on this item	[c] : trp-LName: L-Tryptophan Formula: C11H12N2O2 Charge: 0 click to see details on this item + thbptName: Tetrahydrobiopterin Formula: C9H15N5O3 Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + thbpt4acamName: Tetrahydrobiopterin-4a-carbinolamine Formula: C9H15N5O4 Charge: 0 click to see details on this item	tph-1	Folate biosynthesis
RC02701Name: 5-Hydroxy-L-tryptophan decarboxy-lyase Type: Regular Location: Cytosol KEGG ID: R02701 click to see details on this item	4.1.1.28Name: aromatic-L-amino-acid decarboxylase Other names: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming) click to see details on this item	[c] : 5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		srtnName: Serotonin Formula: C10H13N2O Charge: 1 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	bas-1	Tryptophan degradation
TCE0600Name: 5-Hydroxy-L-tryptophan transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	(3.0) 5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item[c] + (2.0) atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item[c] + (2.0) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item[c]		(3.0) 5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item[e] + (2.0) adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item[c] + (2.0) hName: H+ Formula: H Charge: 1 click to see details on this item[c] + (2.0) piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item[c]	Not determined	Transport
EX00643Name: 5-Hydroxy-L-tryptophan exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	5htrpName: 5-Hydroxy-L-tryptophan Formula: C11H12N2O3 Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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