Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Pathway Overview

Name .....................................................	:	Lysine degradation
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	7
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	Lysine degradation

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM00716Name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) Type: Regular Location: Mitochondria KEGG ID: R00716 click to see details on this item	1.5.1.8Name: saccharopine dehydrogenase (NADP+, L-lysine-forming) Other names: lysine-2-oxoglutarate reductase, lysine-ketoglutarate reductase, L-lysine-alpha-ketoglutarate reductase, lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming), saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase, 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) click to see details on this item	[m] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + lys-LName: L-Lysine Formula: C6H15N2O2 Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + saccrp-LName: L-Saccharopine Formula: C11H19N2O6 Charge: -1 click to see details on this item	R02D3.1	Lysine degradation
RM02313Name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R02313 click to see details on this item	1.5.1.9Name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) Other names: dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), saccharopin dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming), aminoadipic semialdehyde synthase, 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) click to see details on this item	[m] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + saccrp-LName: L-Saccharopine Formula: C11H19N2O6 Charge: -1 click to see details on this item		L2aadp6saName: L-2-Aminoadipate 6-semialdehyde Formula: C6H11NO3 Charge: 0 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	R02D3.1	Lysine degradation
RM03102Name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03102 click to see details on this item	1.2.1.31Name: L-aminoadipate-semialdehyde dehydrogenase Other names: aminoadipate semialdehyde dehydrogenase, 2-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipate reductase, 2-aminoadipic semialdehyde dehydrogenase, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase, L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase click to see details on this item	[m] : L2aadp6saName: L-2-Aminoadipate 6-semialdehyde Formula: C6H11NO3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		L2aadpName: L-2-Aminoadipate Formula: C6H10NO4 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	alh-9	Lysine degradation
RM03103Name: L-2-Aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03103 click to see details on this item	1.2.1.31Name: L-aminoadipate-semialdehyde dehydrogenase Other names: aminoadipate semialdehyde dehydrogenase, 2-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipate reductase, 2-aminoadipic semialdehyde dehydrogenase, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase, L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase click to see details on this item	[m] : L2aadp6saName: L-2-Aminoadipate 6-semialdehyde Formula: C6H11NO3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		L2aadpName: L-2-Aminoadipate Formula: C6H10NO4 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	alh-9	Lysine degradation
RMC0014Name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating); Glutaryl-CoA:dihydrolipoamide S-succinyltransferase; Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ Type: Regular Location: Mitochondria KEGG ID: R01940;R02571;R07618 click to see details on this item	1.2.4.2Name: oxoglutarate dehydrogenase (succinyl-transferring) Other names: 2-ketoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase, 2-oxoglutarate: lipoate oxidoreductase, 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating), alpha-ketoglutarate dehydrogenase, alphaketoglutaric acid dehydrogenase, alpha-ketoglutaric dehydrogenase, alpha-oxoglutarate dehydrogenase, AKGDH, OGDC, ketoglutaric dehydrogenase, oxoglutarate decarboxylase, oxoglutarate dehydrogenase, oxoglutarate dehydrogenase (lipoamide) click to see details on this item 2.3.1.61Name: dihydrolipoyllysine-residue succinyltransferase Other names: dihydrolipoamide S-succinyltransferase, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl transsuccinylase, dihydrolipoyl transsuccinylase, lipoate succinyltransferase (Escherichia coli), lipoic transsuccinylase, lipoyl transsuccinylase, succinyl-CoA:dihydrolipoamide S-succinyltransferase, succinyl-CoA:dihydrolipoate S-succinyltransferase, enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item	[m] : 2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + glutcoaName: Glutaryl-CoA Formula: C26H37N7O19P3S Charge: -5 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	(ogdh-1 & ogdh-2) & dlst-1 & dld-1	Lysine degradation
RM02488Name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Type: Regular Location: Mitochondria KEGG ID: R02488 click to see details on this item	1.3.8.6Name: glutaryl-CoA dehydrogenase (ETF) Other names: glutaryl coenzyme A dehydrogenase, glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating), glutaryl-CoA dehydrogenase click to see details on this item	[m] : etfoxName: Electron transfer flavoprotein oxidized Formula: R Charge: 0 click to see details on this item + glutcoaName: Glutaryl-CoA Formula: C26H37N7O19P3S Charge: -5 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		b2coaName: Crotonoyl-CoA Formula: C25H36N7O17P3S Charge: -4 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + etfrdName: Electron transfer flavoprotein reduced Formula: RH2 Charge: 0 click to see details on this item	F54D5.7	Lysine degradation
RM01939Name: L-2-aminoadipate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R01939 click to see details on this item	2.6.1.39Name: 2-aminoadipate transaminase Other names: alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, glutamic-ketoadipic transaminase, glutamate-alpha-ketoadipate transaminase click to see details on this item	[m] : L2aadpName: L-2-Aminoadipate Formula: C6H10NO4 Charge: -1 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item		2oxoadpName: 2-Oxoadipate Formula: C6H6O5 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	To be determined	Lysine degradation

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