WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	tag
Name .....................................................	:	triacylglycerol, etc.Triglyceride
Model ID .....................................................	:	C00422
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00422
Formula .....................................................	:	C3H5FULLR4CO2FULLR5CO2FULLR3CO2
Charge .....................................................	:	0
Localization .....................................................	:	Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	tag_hs
Other associations .....................................................	:	See reaction table below (9 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Glycerolipid metabolism (c,e)

iCEL1314

Comments

Charge is obvious based on general rules and similar compounds.

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC02251Name: acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase Type: Regular Location: Cytosol KEGG ID: R02251 click to see details on this item	2.3.1.20Name: diacylglycerol O-acyltransferase Other names: diglyceride acyltransferase, 1,2-diacylglycerol acyltransferase, diacylglycerol acyltransferase, diglyceride O-acyltransferase, palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase, acyl-CoA:1,2-diacylglycerol O-acyltransferase click to see details on this item	[c] : Rtotal3coaName: R total 3 Coenzyme A Formula: CO2FULLR3C21H31N7O15P3S Charge: -4 click to see details on this item + dag_tagName: diacylglycerol (TAG) Formula: C3H6OFULLR4CO2FULLR5CO2 Charge: 0 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item	mboa-2	Glycerolipid metabolism
RC02250Name: Triacylglycerol acylhydrolase Type: Regular Location: Cytosol KEGG ID: R02250;R01369 click to see details on this item	3.1.1.3Name: triacylglycerol lipase Other names: lipase (ambiguous), butyrinase, tributyrinase, Tween hydrolase, steapsin, triacetinase, tributyrin esterase, Tweenase, amno N-AP, Takedo 1969-4-9, Meito MY 30, Tweenesterase, GA 56, capalase L, triglyceride hydrolase, triolein hydrolase, tween-hydrolyzing esterase, amano CE, cacordase, triglyceridase, triacylglycerol ester hydrolase, amano P, amano AP, PPL, glycerol-ester hydrolase, GEH, meito Sangyo OF lipase, hepatic lipase, lipazin, post-heparin plasma protamine-resistant lipase, salt-resistant post-heparin lipase, heparin releasable hepatic lipase, amano CES, amano B, tributyrase, triglyceride lipase, liver lipase, hepatic monoacylglycerol acyltransferase click to see details on this item 3.1.1.79Name: hormone-sensitive lipase Other names: HSL click to see details on this item	[c] : tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		dag_tagName: diacylglycerol (TAG) Formula: C3H6OFULLR4CO2FULLR5CO2 Charge: 0 click to see details on this item + Rtotal3Name: R total 3 position Formula: CO2FULLR3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	atgl-1 \| hosl-1	Glycerolipid metabolism
BIO0100Name: Assembly of biomass (without DNA) Type: Biomass Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	(0.202508) collgName: Collagen Formula: X Charge: 0 click to see details on this item[c] + (0.204599) glycogenName: glycogen Formula: C6H10O5 Charge: 0 click to see details on this item[c] + (0.058654) GlycansName: Glycan pool Formula: X Charge: 0 click to see details on this item[c] + (0.188823) RNAName: RNA (biomass) Formula: X Charge: 0 click to see details on this item[c] + (0.129849) PhosphoLName: Phospholipids Formula: X Charge: 0 click to see details on this item[c] + (0.029368) treName: Trehalose Formula: C12H22O11 Charge: 0 click to see details on this item[c] + (0.0001) biomass_minorName: Minor components of biomass Formula: X Charge: 0 click to see details on this item[c] + (1.152647) prot_mitoName: Mitochondrial protein Formula: X Charge: 0 click to see details on this item[m] + (0.117468) tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[c] + (4.028712) prot_otherName: Non-mitochondrial protein Formula: X Charge: 0 click to see details on this item[c]		BiomassName: Body Biomass Formula: X Charge: 0 click to see details on this item[c]	Not applicable	Biomass assembly
BIO0102Name: Assembly of biomass (without collagen) Type: Biomass Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	(0.016249) DNAName: DNA (biomass) Formula: X Charge: 0 click to see details on this item[c] + (0.203528) glycogenName: glycogen Formula: C6H10O5 Charge: 0 click to see details on this item[c] + (0.058347) GlycansName: Glycan pool Formula: X Charge: 0 click to see details on this item[c] + (0.187835) RNAName: RNA (biomass) Formula: X Charge: 0 click to see details on this item[c] + (0.129169) PhosphoLName: Phospholipids Formula: X Charge: 0 click to see details on this item[c] + (0.029215) treName: Trehalose Formula: C12H22O11 Charge: 0 click to see details on this item[c] + (0.0001) biomass_minorName: Minor components of biomass Formula: X Charge: 0 click to see details on this item[c] + (1.146612) prot_mitoName: Mitochondrial protein Formula: X Charge: 0 click to see details on this item[m] + (0.116853) tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[c] + (4.580136) prot_otherName: Non-mitochondrial protein Formula: X Charge: 0 click to see details on this item[c]		BiomassName: Body Biomass Formula: X Charge: 0 click to see details on this item[c]	Not applicable	Biomass assembly
BIO0104Name: Assembly of biomass (without DNA or collagen) Type: Biomass Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	(0.204599) glycogenName: glycogen Formula: C6H10O5 Charge: 0 click to see details on this item[c] + (0.058654) GlycansName: Glycan pool Formula: X Charge: 0 click to see details on this item[c] + (0.188823) RNAName: RNA (biomass) Formula: X Charge: 0 click to see details on this item[c] + (0.129849) PhosphoLName: Phospholipids Formula: X Charge: 0 click to see details on this item[c] + (0.029368) treName: Trehalose Formula: C12H22O11 Charge: 0 click to see details on this item[c] + (0.0001) biomass_minorName: Minor components of biomass Formula: X Charge: 0 click to see details on this item[c] + (1.152647) prot_mitoName: Mitochondrial protein Formula: X Charge: 0 click to see details on this item[m] + (0.117468) tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[c] + (4.604242) prot_otherName: Non-mitochondrial protein Formula: X Charge: 0 click to see details on this item[c]		BiomassName: Body Biomass Formula: X Charge: 0 click to see details on this item[c]	Not applicable	Biomass assembly
BIO0107Name: Assembly of biomass (all components included) Type: Biomass Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	(0.201448) collgName: Collagen Formula: X Charge: 0 click to see details on this item[c] + (0.016249) DNAName: DNA (biomass) Formula: X Charge: 0 click to see details on this item[c] + (0.203528) glycogenName: glycogen Formula: C6H10O5 Charge: 0 click to see details on this item[c] + (0.058347) GlycansName: Glycan pool Formula: X Charge: 0 click to see details on this item[c] + (0.187835) RNAName: RNA (biomass) Formula: X Charge: 0 click to see details on this item[c] + (0.129169) PhosphoLName: Phospholipids Formula: X Charge: 0 click to see details on this item[c] + (0.029215) treName: Trehalose Formula: C12H22O11 Charge: 0 click to see details on this item[c] + (0.0001) biomass_minorName: Minor components of biomass Formula: X Charge: 0 click to see details on this item[c] + (1.146612) prot_mitoName: Mitochondrial protein Formula: X Charge: 0 click to see details on this item[m] + (0.116853) tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[c] + (4.007619) prot_otherName: Non-mitochondrial protein Formula: X Charge: 0 click to see details on this item[c]		BiomassName: Body Biomass Formula: X Charge: 0 click to see details on this item[c]	Not applicable	Biomass assembly
SNK0014Name: triglyceride (fat) sink Type: Sink Location: Cytosol KEGG ID: NA click to see details on this item	Not applicable	tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[c]			Not applicable	Sink reactions
TCE5381Name: triacylglycerol transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[e]		tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[c]	Not determined	Transport
EX00422Name: triacylglycerol exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	tagName: triacylglycerol Formula: C3H5FULLR4CO2FULLR5CO2FULLR3CO2 Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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