Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	dtmp
Name .....................................................	:	dTMP, etc.Thymidine 5'-phosphate, Deoxythymidine 5'-phosphate, Thymidylic acid, 5'-Thymidylic acid, Thymidine monophosphate, Deoxythymidylic acid, Thymidylate
Model ID .....................................................	:	C00364
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00364
Formula .....................................................	:	C10H13N2O8P
Charge .....................................................	:	-2
Localization .....................................................	:	Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	dtmp
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate cycle (c), Pyrimidine metabolism (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC02101Name: 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase Type: Regular Location: Cytosol KEGG ID: R02101 click to see details on this item	2.1.1.45Name: thymidylate synthase Other names: dTMP synthase, thymidylate synthetase, methylenetetrahydrofolate:dUMP C-methyltransferase, TMP synthetase click to see details on this item	[c] : dumpName: dUMP Formula: C9H11N2O8P Charge: -2 click to see details on this item + mlthfName: "5,10-Methylenetetrahydrofolate" Formula: C20H21N7O6 Charge: -2 click to see details on this item		dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item + dtmpName: dTMP Formula: C10H13N2O8P Charge: -2 click to see details on this item	tyms-1	Folate cycle
RC02094Name: ATP:dTMP phosphotransferase Type: Regular Location: Cytosol KEGG ID: R02094 click to see details on this item	2.7.4.9Name: dTMP kinase Other names: thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, thymidine 5'-monophosphate kinase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + dtmpName: dTMP Formula: C10H13N2O8P Charge: -2 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + dtdpName: dTDP Formula: C10H13N2O11P2 Charge: -3 click to see details on this item	dtmk-1	Pyrimidine metabolism
RC01569Name: Thymidylate 5-phosphohydrolase Type: Regular Location: Cytosol KEGG ID: R01569 click to see details on this item	3.1.3.5Name: 5'-nucleotidase Other names: uridine 5'-nucleotidase, 5'-adenylic phosphatase, adenosine 5'-phosphatase, AMP phosphatase, adenosine monophosphatase, 5'-mononucleotidase, AMPase, UMPase, snake venom 5'-nucleotidase, thimidine monophosphate nucleotidase, 5'-AMPase, 5'-AMP nucleotidase, AMP phosphohydrolase, IMP 5'-nucleotidase click to see details on this item	[c] : dtmpName: dTMP Formula: C10H13N2O8P Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + thymdName: Thymidine Formula: C10H14N2O5 Charge: 0 click to see details on this item	F25B5.3 | Y10G11A.1 | Y71H10B.1	Pyrimidine metabolism
RC01567Name: ATP:thymidine 5-phosphotransferase Type: Regular Location: Cytosol KEGG ID: R01567 click to see details on this item	2.7.1.21Name: thymidine kinase Other names: thymidine kinase (phosphorylating), 2'-deoxythymidine kinase, deoxythymidine kinase (phosphorylating) click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + thymdName: Thymidine Formula: C10H14N2O5 Charge: 0 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + dtmpName: dTMP Formula: C10H13N2O8P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	thk-1	Pyrimidine metabolism
DGR0003Name: Bacterial DNA degradation Type: Degradation Location: Cytosol KEGG ID: NA click to see details on this item	Not applicable	[c] : dna_BACName: DNA component of bacterial diet Formula: X Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		(0.246507) dampName: dAMP Formula: C10H12N5O6P Charge: -2 click to see details on this item + (0.253493) dcmpName: dCMP Formula: C9H12N3O7P Charge: -2 click to see details on this item + (0.253493) dgmpName: dGMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + (0.246507) dtmpName: dTMP Formula: C10H13N2O8P Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Not determined	Bacterial digestion

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