Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	dhf
Name .....................................................	:	"7,8-Dihydrofolate", etc.Dihydrofolate, Dihydrofolic acid, 7,8-Dihydrofolate, 7,8-Dihydrofolic acid, 7,8-Dihydropteroylglutamate
Model ID .....................................................	:	C00415
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00415
Formula .....................................................	:	C19H19N7O6
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	dhf
Other associations .....................................................	:	See reaction table below (6 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate cycle (c), Pyrimidine metabolism (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00936Name: 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00936 click to see details on this item	1.5.1.3Name: dihydrofolate reductase Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase click to see details on this item	[c] : dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate" Formula: C19H21N7O6 Charge: -2 click to see details on this item	dhfr-1	Folate cycle
RC00939Name: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00939 click to see details on this item	1.5.1.3Name: dihydrofolate reductase Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase click to see details on this item	[c] : dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate" Formula: C19H21N7O6 Charge: -2 click to see details on this item	dhfr-1	Folate cycle
RC02235Name: dihydrofolate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R02235 click to see details on this item	1.5.1.3Name: dihydrofolate reductase Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase click to see details on this item	[c] : folName: Folate Formula: C19H18N7O6 Charge: -1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	dhfr-1	Folate cycle
RC02236Name: dihydrofolate:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R02236 click to see details on this item	1.5.1.3Name: dihydrofolate reductase Other names: tetrahydrofolate dehydrogenase, DHFR, pteridine reductase:dihydrofolate reductase, dihydrofolate reductase:thymidylate synthase, thymidylate synthetase-dihydrofolate reductase, folic acid reductase, folic reductase, dihydrofolic acid reductase, dihydrofolic reductase, 7,8-dihydrofolate reductase, NADPH-dihydrofolate reductase click to see details on this item	[c] : folName: Folate Formula: C19H18N7O6 Charge: -1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	dhfr-1	Folate cycle
RC02101Name: 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase Type: Regular Location: Cytosol KEGG ID: R02101 click to see details on this item	2.1.1.45Name: thymidylate synthase Other names: dTMP synthase, thymidylate synthetase, methylenetetrahydrofolate:dUMP C-methyltransferase, TMP synthetase click to see details on this item	[c] : dumpName: dUMP Formula: C9H11N2O8P Charge: -2 click to see details on this item + mlthfName: "5,10-Methylenetetrahydrofolate" Formula: C20H21N7O6 Charge: -2 click to see details on this item		dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item + dtmpName: dTMP Formula: C10H13N2O8P Charge: -2 click to see details on this item	tyms-1	Folate cycle
TCM1281Name: "7,8-Dihydrofolate" transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item[c]		dhfName: "7,8-Dihydrofolate" Formula: C19H19N7O6 Charge: -2 click to see details on this item[m]	Not determined	Transport

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