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" for efficient search:
?
: A single character.
E.g.
,
trehalose?phosphatase
covers both
trehalose phosphatase
and
trehalose-phosphatase
, of which, only the latter fits the nomenclature used in this database.
*
: Any number of characters.
E.g.
,
tre-*
brings all genes from trehalase family;
coenzyme*A
covers
coenzyme A
,
coenzyme-A
, and
coenzymeA
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Network
Biomass
WormPaths
FBA
F
lux
B
alance
A
nalysis
PEA
P
athway
E
nrichment
A
nalysis
WormClust
Clustering- and enrichment-based association of genes with the metabolic network
Enzyme Overview
Enzyme
(?)
Identification in
Enzyme Commission (EC)
numbering system.
.....................................................
:
2.1.1.43
Name
.....................................................
:
Histone-lysine N-methyltransferase,
etc.
Protein methylase III, Protein methylase 3, Protein (lysine) methyltransferase, Protein methyltransferase II, Protein-lysine N-methyltransferase, Histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
KO
(?)
The
KEGG
orthology group (KO) that is associated with this enzyme.
.....................................................
:
K11423
SETD2 SET2; histone-lysine N-methyltransferase SETD2 [EC:2.1.1.43]
,
K06101
ASH1L; histone-lysine N-methyltransferase ASH1L [EC:2.1.1.43]
,
K11421
SETDB; histone-lysine N-methyltransferase SETDB [EC:2.1.1.43]
,
K11433
SETMAR; histone-lysine N-methyltransferase SETMAR [EC:2.1.1.43]
,
K11430
EZH2; histone-lysine N-methyltransferase EZH2 [EC:2.1.1.43]
,
K09188
MLL3; histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
,
K11422
SETD1 SET1; histone-lysine N-methyltransferase SETD1 [EC:2.1.1.43]
,
K11428
SETD8; histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]
,
K11429
SUV420H; histone-lysine N-methyltransferase SUV420H [EC:2.1.1.43]
,
K11427
DOT1L DOT1; histone-lysine N-methyltransferase H3 lysine-79 specific [EC:2.1.1.43]
,
K11420
EHMT; euchromatic histone-lysine N-methyltransferase [EC:2.1.1.43]
Genes
.....................................................
:
dot-1.1
,
dot-1.2
,
dot-1.3
,
dot-1.4
,
dot-1.5
,
lin-59
,
mes-2
,
met-1
,
met-2
,
set-1
,
set-11
,
set-12
,
set-13
,
set-15
,
set-16
,
set-2
,
set-21
,
set-23
,
set-32
,
set-33
,
set-4
,
set-6
Localization
.....................................................
:
Cytosol
Other associations
.....................................................
:
See reaction table below
.
External links
KEGG
BRENDA
Reactions
ID
Enzyme
Reactants
Products
Genes
(?)
Multiple genes are separated by OR (
I
) or AND (
&
).
I
indicates that genes are
redundant
within the group (
e.g.
paralogs encoding the same enzyme).
&
indicates that genes are
non-redundant
within the group (
e.g.
genes encoding different subunits of the same enzyme).
If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs,
each group with multiple genes is shown in parentheses
.
Pathway
RCC0177
Name:
Protein-lysine methylase
Type:
Regular
Location:
Cytosol
KEGG ID:
R03875;R04866;R04867
click to see details on this item
2.1.1.43
Name:
histone-lysine N-methyltransferase
Other names:
protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
click to see details on this item
[c] :
peplys
Name:
Peptidyl-L-lysine
Formula:
XC6H13N2O
Charge:
1
click to see details on this item
+ (3)
amet
Name:
S-Adenosyl-L-methionine
Formula:
C15H23N6O5S
Charge:
1
click to see details on this item
peptmelys
Name:
Protein N6,N6,N6-trimethyl-L-lysine
Formula:
XC9H19N2O
Charge:
1
click to see details on this item
+ (3)
ahcys
Name:
S-Adenosyl-L-homocysteine
Formula:
C14H20N6O5S
Charge:
0
click to see details on this item
+ (3)
h
Name:
H+
Formula:
H
Charge:
1
click to see details on this item
[
set-16
|
lin-59
| (
met-1
|
set-12
) |
set-2
|
met-2
|
set-11
|
mes-2
|
set-23
| (
dot-1.1
|
dot-1.2
|
dot-1.3
|
dot-1.4
|
dot-1.5
) |
set-4
|
set-1
] | [
set-13
|
set-15
|
set-21
|
set-32
|
set-33
|
set-6
]
Carnitine biosynthesis
RC03875
Name:
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
Type:
Regular
Location:
Cytosol
KEGG ID:
R03875
click to see details on this item
2.1.1.43
Name:
histone-lysine N-methyltransferase
Other names:
protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
click to see details on this item
[c] :
amet
Name:
S-Adenosyl-L-methionine
Formula:
C15H23N6O5S
Charge:
1
click to see details on this item
+
Nlys
Name:
Histone-L-Lysine
Formula:
XC6H13N2O
Charge:
1
click to see details on this item
Nmelys
Name:
Histone N6-methyl-L-lysine
Formula:
XC7H15N2O
Charge:
1
click to see details on this item
+
ahcys
Name:
S-Adenosyl-L-homocysteine
Formula:
C14H20N6O5S
Charge:
0
click to see details on this item
+
h
Name:
H+
Formula:
H
Charge:
1
click to see details on this item
[
set-16
|
lin-59
| (
met-1
|
set-12
) |
set-2
|
met-2
|
set-11
|
mes-2
|
set-23
| (
dot-1.1
|
dot-1.2
|
dot-1.3
|
dot-1.4
|
dot-1.5
) |
set-4
|
set-1
] | [
set-13
|
set-15
|
set-21
|
set-32
|
set-33
|
set-6
]
Histone modification
RC04866
Name:
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase (acting on monomethylated residues)
Type:
Regular
Location:
Cytosol
KEGG ID:
R04866
click to see details on this item
2.1.1.43
Name:
histone-lysine N-methyltransferase
Other names:
protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
click to see details on this item
[c] :
Nmelys
Name:
Histone N6-methyl-L-lysine
Formula:
XC7H15N2O
Charge:
1
click to see details on this item
+
amet
Name:
S-Adenosyl-L-methionine
Formula:
C15H23N6O5S
Charge:
1
click to see details on this item
Ndmelys
Name:
Histone N6,N6-dimethyl-L-lysine
Formula:
XC8H17N2O
Charge:
1
click to see details on this item
+
ahcys
Name:
S-Adenosyl-L-homocysteine
Formula:
C14H20N6O5S
Charge:
0
click to see details on this item
+
h
Name:
H+
Formula:
H
Charge:
1
click to see details on this item
[
set-16
|
lin-59
| (
met-1
|
set-12
) |
set-2
|
met-2
|
set-11
|
mes-2
|
set-23
| (
dot-1.1
|
dot-1.2
|
dot-1.3
|
dot-1.4
|
dot-1.5
) |
set-4
|
set-1
] | [
set-13
|
set-15
|
set-21
|
set-32
|
set-33
|
set-6
]
Histone modification
RC04867
Name:
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase (acting on dimethylated residues)
Type:
Regular
Location:
Cytosol
KEGG ID:
R04867
click to see details on this item
2.1.1.43
Name:
histone-lysine N-methyltransferase
Other names:
protein methylase III, protein methylase 3, protein (lysine) methyltransferase, protein methyltransferase II, protein-lysine N-methyltransferase, histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase, S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
click to see details on this item
[c] :
Ndmelys
Name:
Histone N6,N6-dimethyl-L-lysine
Formula:
XC8H17N2O
Charge:
1
click to see details on this item
+
amet
Name:
S-Adenosyl-L-methionine
Formula:
C15H23N6O5S
Charge:
1
click to see details on this item
Ntmelys
Name:
Histone N6,N6,N6-trimethyl-L-lysine
Formula:
XC9H19N2O
Charge:
1
click to see details on this item
+
ahcys
Name:
S-Adenosyl-L-homocysteine
Formula:
C14H20N6O5S
Charge:
0
click to see details on this item
+
h
Name:
H+
Formula:
H
Charge:
1
click to see details on this item
[
set-16
|
lin-59
| (
met-1
|
set-12
) |
set-2
|
met-2
|
set-11
|
mes-2
|
set-23
| (
dot-1.1
|
dot-1.2
|
dot-1.3
|
dot-1.4
|
dot-1.5
) |
set-4
|
set-1
] | [
set-13
|
set-15
|
set-21
|
set-32
|
set-33
|
set-6
]
Histone modification
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