WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.3.1.2
Name .....................................................	:	Dihydropyrimidine dehydrogenase (NADP+), etc.Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase (NADP+), 4,5-dihydrothymine: oxidoreductase, DPD, DHPDH, Dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHU dehydrogenase, Hydropyrimidine dehydrogenase, Dihydropyrimidine dehydrogenase (NADP)
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00207DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Genes .....................................................	:	dpyd-1
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00978Name: 5,6-Dihydrouracil:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00978 click to see details on this item	1.3.1.2Name: dihydropyrimidine dehydrogenase (NADP+) Other names: dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NADP+), 4,5-dihydrothymine: oxidoreductase, DPD, DHPDH, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHU dehydrogenase, hydropyrimidine dehydrogenase, dihydropyrimidine dehydrogenase (NADP) click to see details on this item	[c] : 56duraName: "5,6-dihydrouracil" Formula: C4H6N2O2 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + uraName: Uracil Formula: C4H4N2O2 Charge: 0 click to see details on this item	dpyd-1	Pyrimidine metabolism
RC01415Name: 5,6-Dihydrothymine:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01415 click to see details on this item	1.3.1.2Name: dihydropyrimidine dehydrogenase (NADP+) Other names: dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NADP+), 4,5-dihydrothymine: oxidoreductase, DPD, DHPDH, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHU dehydrogenase, hydropyrimidine dehydrogenase, dihydropyrimidine dehydrogenase (NADP) click to see details on this item	[c] : 56dthmName: "5,6-Dihydrothymine" Formula: C5H8N2O2 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + thymName: Thymine Formula: C5H6N2O2 Charge: 0 click to see details on this item	dpyd-1	Pyrimidine metabolism

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