WormFlux: mechanistic analysis of C. elegans metabolism

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? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	56dura
Name .....................................................	:	"5,6-dihydrouracil", etc.5,6-Dihydrouracil, Dihydro-2,4(1H,3H)-pyrimidinedione, Dihydrouracile, Dihydrouracil, 5,6-Dihydro-2,4-dihydroxypyrimidine, Hydrouracil, 2,4-Dioxotetrahydropyrimidine
Model ID .....................................................	:	C00429
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00429
Formula .....................................................	:	C4H6N2O2
Charge .....................................................	:	0
Localization .....................................................	:	Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	56dura
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Pyrimidine metabolism (c)

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00978Name: 5,6-Dihydrouracil:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00978 click to see details on this item	1.3.1.2Name: dihydropyrimidine dehydrogenase (NADP+) Other names: dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NADP+), 4,5-dihydrothymine: oxidoreductase, DPD, DHPDH, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHU dehydrogenase, hydropyrimidine dehydrogenase, dihydropyrimidine dehydrogenase (NADP) click to see details on this item	[c] : 56duraName: "5,6-dihydrouracil" Formula: C4H6N2O2 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + uraName: Uracil Formula: C4H4N2O2 Charge: 0 click to see details on this item	dpyd-1	Pyrimidine metabolism
RC02269Name: 5,6-Dihydrouracil amidohydrolase Type: Regular Location: Cytosol KEGG ID: R02269 click to see details on this item	3.5.2.2Name: dihydropyrimidinase Other names: hydantoinase, hydropyrimidine hydrase, hydantoin peptidase, pyrimidine hydrase, D-hydantoinase click to see details on this item	[c] : 56duraName: "5,6-dihydrouracil" Formula: C4H6N2O2 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		calaName: N-Carbamoyl-beta-alanine Formula: C4H7N2O3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	dhp-1 \| dhp-2	Pyrimidine metabolism
TCE5363Name: 5,6-dihydrouracil transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	56duraName: "5,6-dihydrouracil" Formula: C4H6N2O2 Charge: 0 click to see details on this item[c]		56duraName: "5,6-dihydrouracil" Formula: C4H6N2O2 Charge: 0 click to see details on this item[e]	Not determined	Transport
EX00429Name: "5,6-dihydrouracil" exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	56duraName: "5,6-dihydrouracil" Formula: C4H6N2O2 Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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