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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal
Enzyme Overview
Enzyme (?) Identification in Enzyme Commission (EC) numbering system. ..................................................... : 1.2.4.1
Name ..................................................... : Pyruvate dehydrogenase (acetyl-transferring), etc.MtPDC (mitochondrial pyruvate dehydogenase complex), Pyruvate decarboxylase, Pyruvate dehydrogenase, Pyruvate dehydrogenase (lipoamide), Pyruvate dehydrogenase complex, Pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating), Pyruvic acid dehydrogenase, Pyruvic dehydrogenase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. ..................................................... : K00162PDHB pdhB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1], K00161PDHA pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Genes ..................................................... : pdha-1, pdhb-1
Localization ..................................................... : Mitochondria
Other associations ..................................................... : See reaction table below.
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
RM00209Name: pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating)
Type: Regular
Location: Mitochondria
KEGG ID: R00209

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1.2.4.1Name: pyruvate dehydrogenase (acetyl-transferring)
Other names: MtPDC (mitochondrial pyruvate dehydogenase complex), pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase (lipoamide), pyruvate dehydrogenase complex, pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating), pyruvic acid dehydrogenase, pyruvic dehydrogenase

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1.8.1.4Name: dihydrolipoyl dehydrogenase
Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase

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2.3.1.12Name: dihydrolipoyllysine-residue acetyltransferase
Other names: acetyl-CoA:dihydrolipoamide S-acetyltransferase, dihydrolipoamide S-acetyltransferase, dihydrolipoate acetyltransferase, dihydrolipoic transacetylase, dihydrolipoyl acetyltransferase, lipoate acetyltransferase, lipoate transacetylase, lipoic acetyltransferase, lipoic acid acetyltransferase, lipoic transacetylase, lipoylacetyltransferase, thioltransacetylase A, transacetylase X, enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase, acetyl-CoA:enzyme 6-N-(dihydrolipoyl)lysine S-acetyltransferase

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[m] : pyrName: Pyruvate
Formula: C3H3O3
Charge: -1




click to see details on this item + coaName: Coenzyme A
Formula: C21H32N7O16P3S
Charge: -4




click to see details on this item + nadName: Nicotinamide adenine dinucleotide
Formula: C21H26N7O14P2
Charge: -1




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accoaName: Acetyl-CoA
Formula: C23H34N7O17P3S
Charge: -4




click to see details on this item + co2Name: CO2
Formula: CO2
Charge: 0




click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced
Formula: C21H27N7O14P2
Charge: -2




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(pdha-1 & pdhb-1) & (dlat-2 | dlat-1) & dld-1
Glycolysis / gluconeogenesis
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