Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	2mop
Name .....................................................	:	2-Methyl-3-oxopropanoate, etc.(S)-Methylmalonate semialdehyde
Model ID .....................................................	:	C06002
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C06002
Formula .....................................................	:	C4H5O3
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	2mop
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Alanine metabolism (m), Propionate degradation (m), Valine degradation (m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM02050Name: (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R02050 click to see details on this item	2.6.1.40Name: (R)-3-amino-2-methylpropionate---pyruvate transaminase Other names: D-3-aminoisobutyrate---pyruvate transaminase, beta-aminoisobutyrate-pyruvate aminotransferase, D-3-aminoisobutyrate-pyruvate aminotransferase, D-3-aminoisobutyrate-pyruvate transaminase, (R)-3-amino-2-methylpropionate transaminase, D-beta-aminoisobutyrate:pyruvate aminotransferase click to see details on this item	[m] : 3aib-DName: D-3-Amino-isobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item + pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item		2mopName: 2-Methyl-3-oxopropanoate Formula: C4H5O3 Charge: -1 click to see details on this item + ala-LName: L-Alanine Formula: C3H7NO2 Charge: 0 click to see details on this item	T09B4.8	Alanine metabolism
RM05066Name: 3-Hydroxy-2-methylpropanoate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R05066 click to see details on this item	1.1.1.31Name: 3-hydroxyisobutyrate dehydrogenase Other names: beta-hydroxyisobutyrate dehydrogenase click to see details on this item 1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[m] : 3hmpName: 3-Hydroxy-2-methylpropanoate Formula: C4H7O3 Charge: -1 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		2mopName: 2-Methyl-3-oxopropanoate Formula: C4H5O3 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	B0250.5 | (B0272.3 | F54C8.1 | ech-8 | ech-9 | hacd-1)	Valine degradation
RM04188Name: L-3-amino-isobutanoate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R04188 click to see details on this item	2.6.1.22Name: (S)-3-amino-2-methylpropionate transaminase Other names: L-3-aminoisobutyrate transaminase, beta-aminobutyric transaminase, L-3-aminoisobutyric aminotransferase, beta-aminoisobutyrate-alpha-ketoglutarate transaminase click to see details on this item	[m] : 2mopName: 2-Methyl-3-oxopropanoate Formula: C4H5O3 Charge: -1 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item		3aibName: L-3-Amino-isobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item	gta-1	Propionate degradation
RM00935Name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) Type: Regular Location: Mitochondria KEGG ID: R00935 click to see details on this item	1.2.1.27Name: methylmalonate-semialdehyde dehydrogenase (acylating) Other names: MSDH, MMSA dehydrogenase click to see details on this item	[m] : 2mopName: 2-Methyl-3-oxopropanoate Formula: C4H5O3 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item	alh-8	Propionate degradation

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