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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
FBAFlux Balance Analysis PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network
Gene Overview
Name ..................................................... : slc-25A29
Sequence ID ..................................................... : C54G10.4
Status (?) Can be one of the following two: Curated (manually annotated or based on a curated SACURE result), or Not curated (SACURE result reported without manual check). ..................................................... : Curated
KO (?) The KEGG orthology group (KO) that is associated with this gene. ..................................................... : K15109SLC25A20_29 CACT CACL CRC1; solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter) member 20/29
Enzymes in the model (?) Enzymes that are part of the current metabolic network model. ..................................................... : None
Other enzymes (?) Enzymes that are associated with this gene in the WormFlux database, but not included in the current network model. ..................................................... : None
Model reactions (?) Reactions that are part of the current metabolic network model.

See the bottom of this page for a table of reactions. ..................................................... 		: TCM5054, TCM5012, TCM5003, TCM5052, TCM5010, TCM5055, TCM5009, TCM5015, TCM5002, TCM5057, TCM5001, TCM5053, TCM5056, TCM5049, TCM5050, TCM5013, TCM5011, TCM5051, TCM5029, TCM5048, TCM5014
Relevant model reactions (?) Model reactions that follow from the KEGG reactions associated with this gene, but that exclude this gene due to differences in reaction specificity or localization compared to the predictions for this gene. ..................................................... : ERROR
Other reactions (?) KEGG reactions that are associated with this gene in the WormFlux database, but not included in the current network model. ..................................................... : None

In WormPaths (?) Pathway maps where this gene is represented are listed here. ..................................................... : Mitochondrial fatty acid degradation, Propionate degradation
► | Gene-KO-Enzyme-Reaction Associations (click to view)▼ | Gene-KO-Enzyme-Reaction Associations (click to hide)
SACURE (?) Associations established by SACURE (Systematic Annotation by CUration and REgression).

SACURE pipeline annotates genes based on a logistic function that converts evidence from multiple resources into a KEGG orthology decision, which is then associated with enzymes and reactions. False positives and false negatives of the logistic function are separated out during manual curation for making exceptional decisions.

See HELP in the upper menu for a description of the SACURE pipeline.

See below for a summary of association scores from SACURE.

Results (?) KO: Associated KEGG Orthology groups
Enzyme: Associated enzymes in EC numbering
Reactions: Associated reactions from KEGG reaction database.

Confidence level is indicated for each association as a function of overall SACURE score (a probability of true association; see below in the SACURE scores section). Score ranges for HIGH, MEDIUM, and LOW confidence levels are >0.99, 0.90-0.99, and 0.50-0.90, respectively. If an association is accepted with a probability less than 0.50 (due to an exceptional reason), then the confidence level is LOW.

Not determined indicates that annotation analysis resulted in no clear associations.

ID - Confidence
KO K15109 - High
Enzyme None
Reaction None

Comments

  • Based on the logistic function.
  • See scores from predictors and the logistic function below (SACURE summary).

Reconstruction (?) Associations established during the reconstruction process by lenient annotation, literature search, or gap-filling.

Results (?) KO: Associated KEGG Orthology groups
Enzyme: Associated enzymes in EC numbering
Reactions: Associated reactions from KEGG reaction database or custom reactions developed during reconstruction.

ID - Confidence
KO K15109 - High
Enzyme Not available
Reaction TCM5001 - High
TCM5002 - High
TCM5003 - High
TCM5009 - High
TCM5010 - High
TCM5011 - High
TCM5012 - High
TCM5013 - High
TCM5014 - High
TCM5015 - High
TCM5029 - High
TCM5048 - High
TCM5049 - High
TCM5050 - High
TCM5051 - High
TCM5052 - High
TCM5053 - High
TCM5054 - High
TCM5055 - High
TCM5056 - High
TCM5057 - High

Comments

  • Based on the logistic function. Custom reactions used.

► | SACURE Summary (click to view)▼ | SACURE scores (click to hide)

Score table (?) Association scores for KOs best matching to the query gene according to each annotation predictor, and for the accepted KO if there is any (rightmost columns).

The predictors are ordered in decreasing weight of contribution to the decision-making process in SACURE.

See above for the final decision on the annotation of this gene.

Predictor Best scoring KOs Best score K15109 K15109
KEGG (?) Score represents the annotation in KEGG database by June 2014.

Takes a value of either 0 (KO is not associated with the query gene) or 1 (KO is associated with the query gene). 		K15109 1 1 1
Cluster (?) Score represents the degree of relatedness of a KO to the query gene based on the clustering in the phylogenetic tree of protein sequences (see below for the tree).

Takes values from 0 to 1. 		K15109 1.00 1.00 1.00
myKEGG (?) Score represents the degree of relatedness of a KO to the query gene based on the Smith-Waterman alignment of protein sequence with most similar sequences from all organisms in the KEGG database.

Takes values from 0 to 1.

KOunknown indicates the score for sequences without any KO association in KEGG database. 		K15109 0.92 0.92 0.92
Tree (?) Score shows the degree of relatedness of a KO to the query gene based on the density of this KO in the phylogenetic tree of protein sequences (see below for the tree).

Takes values from 0 to 2 as the score is normalized to the second best KO.

KOunknown indicates the score for sequences without any KO association in KEGG database. 		K15109 1.97 1.97 1.97
KOG (?) Score indicates the absence or presence of a KO in association with one of the orthologs of the query gene according to a eukaryotic orthology database independent of KEGG (see HELP in the upper menu for details).

Takes a value of either 0 (absent) or 1 (present). 		Not applicable 0 0 0
WormBase (?) Score represents matching between the KEGG descriptions of a KO (KO name and all related enzyme names) and the descriptions of the query gene in WormBase (gene overview and protein domains).

Value is increased by 0.5 for every perfect word match and reduced by 0.1 for each character interruption. A non-matching word always creates a 0 score.

WormBase description used for this gene was:

Mitochondrial carrier protein $ Mitochondrial substrate carrier $ Mitochondrial substrate/solute carrier 		Not applicable 0.0 0.0 0.0
Overall (?) Overall score from SACURE that represents the logistic-regression-based probability of acceptance of a KO in association with the query gene. K15109 1.000 1.000 1.000
► | Localization scores (click to view)▼ | Localization scores (click to hide)

Score table (?) Localization scores for proteins encoded by the query gene.

Each predictor is used to determine whether the protein is localized to mitochondria or other compartment.

Together with other genes and other predictors, these scores were used in the determination of the subcellular location of reactions associated with the query gene (see below for the reactions).

Predictor Mitochondrial Other
Mitoprot (?) Score represents the predicted probability that the protein is targeted to mitochondria (mitochondrial score) or not (other score) according to Mitoprot (click to reach).

If multiple isofoms of the same protein are available the highest scores are shown for each compartment. 		0.14 0.87
MitoMiner (?) Score evaluates the evidence for mitochondrial targeting based on the orthologs in 12 eukaryotic model organisms that are in the MitoMiner database (click to reach).

If clear orthologs for the query gene are available in MitoMiner organisms, the score takes a value between 0 and 1 as a function of the ratio of orthologs that have hits (contributes to the mitochondrial score) or no hits (determines the other score) in the database. Mitochondrial score is also a function of the strength of the evidence for the orthologs found in the database (experimental evidence is given a higher weight than theoretical evidence during scoring). 		0.93 0.00
UniProt (?) Score shows the subcellular localization of proteins encoded by this gene as reported in UniProt (click to reach) in October 2014.

If a report is available, the score takes a value of either 0 (not reported to be localized to the pertaining compartment) or 1 (reported to be localized to the pertaining compartment). 		Not available Not available
Org. DB (?) Score shows the subcellular localization of proteins encoded by this gene as reported in Organelle Database (click to reach).

If a report is available, the score takes a value of either 0 (not reported to be localized to the pertaining compartment) or 1 (reported to be localized to the pertaining compartment). 		Not available Not available
► | Phylogenetic tree (click to view)▼ | Phylogenetic tree (click to hide)
K15109 FUN:cdu CD36_06740 (R) K15109 SCE:sce YMC1 (R) K15109 ATH:ath BOU (B) K15109 CEL:cel dif-1 (PB) K15101 CEL:cel T10F2.2 (P) K15109 MAM:mcf SLC25A29 (R) K15109 HSA:hsa SLC25A29 (R) K15109 VER:xtr slc25a29 (R) K15109 INV:spu 585283 (R) K15109 PRO:acan ACA1_072910 (R) K15109 NEM:cbr CBG04567 (R) KO-TBD CEL:cel C54G10.4 (SUBJECT) K15109 ART:dya Dyak_GE18921 (R) K15109 DME:dme Dmel_CG4995 (R) K15109 PLA:atr AMTR_s00218p00018110 (R) KOunknown CEL:cel R07B7.10 (P) K15105 CEL:cel K02F3.2 (P) K15115 CEL:cel K01C8.7 (P) 0.1
Sequence labels indicate KO, taxonomy or model organism, organism name (if taxonomic group), and gene name, respectively. CEL, C. elegans; HSA, H. sapiens; DME, D. melanogaster; ATH, A. thaliana; SCE, S. cerevisiae; BAC, bacteria; ARC, archaea; PRO, protists; FUN, fungi; PLA, plants; INV, invertebrates; NEM, nematodes; ART, arthropods; VER, vertebrates; MAM, mammals. Parenthetical information for organisms other than CEL indicates whether the genes are introduced as best matches (B) or reciprocal best hits (R) to the query gene. Parenthetical information for CEL indicates whether the genes are introduced as paralogues (P) of the query gene or as reciprocal best matches to one of the other organisms in the tree (B). Organism abbreviations are from KEGG.
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
TCM5054Name: Carnitine-acylcarnitine translocase (odecrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
odecrnName: Octadecenoyl carnitine
Formula: C25H47NO4
Charge: 0




click to see details on this item[c]
odecrnName: Octadecenoyl carnitine
Formula: C25H47NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5012Name: Carnitine-acylcarnitine translocase (translocating fa19c11crn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa19c11crnName: cis-11,12-methyleneoctadecanoyl carnitine
Formula: C26H49NO4
Charge: 0




click to see details on this item[c]
fa19c11crnName: cis-11,12-methyleneoctadecanoyl carnitine
Formula: C26H49NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5003Name: Carnitine-acylcarnitine translocase (translocating ddcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
ddcrnName: dodecanoyl carnitine
Formula: C19H37NO4
Charge: 0




click to see details on this item[c]
ddcrnName: dodecanoyl carnitine
Formula: C19H37NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5052Name: Carnitine-acylcarnitine translocase (fa8p1n3crn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa8p1n3crnName: Fatty acyl C8:1 carnitine
Formula: C15H27NO4
Charge: 0




click to see details on this item[c]
fa8p1n3crnName: Fatty acyl C8:1 carnitine
Formula: C15H27NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5010Name: Carnitine-acylcarnitine translocase (translocating fa11c3crn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa11c3crnName: cis-3,4-methylenedecanoyl coa
Formula: C18H33NO4
Charge: 0




click to see details on this item[c]
fa11c3crnName: cis-3,4-methylenedecanoyl coa
Formula: C18H33NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5055Name: Carnitine-acylcarnitine translocase (stcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
stcrnName: Stearoylcarnitine
Formula: C25H49NO4
Charge: 0




click to see details on this item[c]
stcrnName: Stearoylcarnitine
Formula: C25H49NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5009Name: Carnitine-acylcarnitine translocase (translocating fa16p1n7crn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa16p1n7crnName: Palmitoleyl carnitine
Formula: C23H43NO4
Charge: 0




click to see details on this item[c]
fa16p1n7crnName: Palmitoleyl carnitine
Formula: C23H43NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5015Name: Carnitine-acylcarnitine translocase (translocating fa9p0isocrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa9p0isocrnName: Fatty acyl (C9:iso) carnitine
Formula: C16H31NO4
Charge: 0




click to see details on this item[c]
fa9p0isocrnName: Fatty acyl (C9:iso) carnitine
Formula: C16H31NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5002Name: Carnitine-acylcarnitine translocase (translocating ttdcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
ttdcrnName: tetradecanoyl carnitine
Formula: C21H41NO4
Charge: 0




click to see details on this item[c]
ttdcrnName: tetradecanoyl carnitine
Formula: C21H41NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5057Name: Carnitine-acylcarnitine translocase (vacccrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
vacccrnName: Vaccenyl carnitine
Formula: C25H47NO4
Charge: 0




click to see details on this item[c]
vacccrnName: Vaccenyl carnitine
Formula: C25H47NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5001Name: Carnitine-acylcarnitine translocase (translocating pmtcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
pmtcrnName: L-Palmitoylcarnitine
Formula: C23H45NO4
Charge: 0




click to see details on this item[c]
pmtcrnName: L-Palmitoylcarnitine
Formula: C23H45NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5053Name: Carnitine-acylcarnitine translocase (lnlccrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
lnlccrnName: Linoleyl carnitine
Formula: C25H45NO4
Charge: 0




click to see details on this item[c]
lnlccrnName: Linoleyl carnitine
Formula: C25H45NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5056Name: Carnitine-acylcarnitine translocase (tmndnccrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
tmndnccrnName: Timnodonyl carnitine
Formula: C27H43NO4
Charge: 0




click to see details on this item[c]
tmndnccrnName: Timnodonyl carnitine
Formula: C27H43NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5049Name: Carnitine-acylcarnitine translocase (arachdcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
arachdcrnName: C20:4 carnitine
Formula: C27H45NO4
Charge: 0




click to see details on this item[c]
arachdcrnName: C20:4 carnitine
Formula: C27H45NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5050Name: Carnitine-acylcarnitine translocase (dlnlcgcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
dlnlcgcrnName: dihomo-gamma-linolenyl carnitine
Formula: C27H47NO4
Charge: 0




click to see details on this item[c]
dlnlcgcrnName: dihomo-gamma-linolenyl carnitine
Formula: C27H47NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5013Name: Carnitine-acylcarnitine translocase (translocating fa15p0isocrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa15p0isocrnName: Fatty acyl (C15:iso) carnitine
Formula: C22H43NO4
Charge: 0




click to see details on this item[c]
fa15p0isocrnName: Fatty acyl (C15:iso) carnitine
Formula: C22H43NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5011Name: Carnitine-acylcarnitine translocase (translocating fa17c9crn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa17c9crnName: cis-9,10-methylenehexadecanoyl carnitine
Formula: C24H45NO4
Charge: 0




click to see details on this item[c]
fa17c9crnName: cis-9,10-methylenehexadecanoyl carnitine
Formula: C24H45NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5051Name: Carnitine-acylcarnitine translocase (eicostetcrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
eicostetcrnName: Eicosatetranoyl carnitine
Formula: C27H45NO4
Charge: 0




click to see details on this item[c]
eicostetcrnName: Eicosatetranoyl carnitine
Formula: C27H45NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5029Name: Carnitine-acylcarnitine translocase
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
pcrnName: Propionyl-carnitine
Formula: C10H19NO4
Charge: 0




click to see details on this item[c]
pcrnName: Propionyl-carnitine
Formula: C10H19NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5048Name: Carnitine-acylcarnitine translocase (occrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
occrnName: Octanoyl carnitine
Formula: C15H29NO4
Charge: 0




click to see details on this item[c]
occrnName: Octanoyl carnitine
Formula: C15H29NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
TCM5014Name: Carnitine-acylcarnitine translocase (translocating fa17p0isocrn)
Type: Transport
Location: Cytosol, Mitochondria
KEGG ID: NA

click to see details on this item
Not applicable
fa17p0isocrnName: Fatty acyl (C17:iso) carnitine
Formula: C24H47NO4
Charge: 0




click to see details on this item[c]
fa17p0isocrnName: Fatty acyl (C17:iso) carnitine
Formula: C24H47NO4
Charge: 0




click to see details on this item[m]
dif-1 | slc-25A29
Transport
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