WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	6.3.4.3
Name .....................................................	:	Formate---tetrahydrofolate ligase, etc.Formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, Tetrahydrofolic formylase, Tetrahydrofolate formylase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00288MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Genes .....................................................	:	K07E3.4
Localization .....................................................	:	Mitochondria, Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC00943Name: Formate:tetrahydrofolate ligase (ADP-forming) Type: Regular Location: Cytosol KEGG ID: R00943 click to see details on this item	6.3.4.3Name: formate---tetrahydrofolate ligase Other names: formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, tetrahydrofolic formylase, tetrahydrofolate formylase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + forName: Formate Formula: CH1O2 Charge: -1 click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate" Formula: C19H21N7O6 Charge: -2 click to see details on this item		10fthfName: 10-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item + adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	K07E3.4	Folate cycle
RM00943Name: Formate:tetrahydrofolate ligase (ADP-forming) Type: Regular Location: Mitochondria KEGG ID: R00943 click to see details on this item	6.3.4.3Name: formate---tetrahydrofolate ligase Other names: formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, tetrahydrofolic formylase, tetrahydrofolate formylase click to see details on this item	[m] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + forName: Formate Formula: CH1O2 Charge: -1 click to see details on this item + thfName: "5,6,7,8-Tetrahydrofolate" Formula: C19H21N7O6 Charge: -2 click to see details on this item		10fthfName: 10-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item + adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	K07E3.4	Folate cycle

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