WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	2.3.1.85
Name .....................................................	:	Fatty-acid synthase, etc.FASN (gene name)
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00665FASN; fatty acid synthase animal type [EC:2.3.1.85]
Genes .....................................................	:	F32H2.6, fasn-1
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0020Name: fatty acid synthetase (palmitate, n-C16:0) Type: Regular Location: Cytosol KEGG ID: R05188 click to see details on this item	2.3.1.85Name: fatty-acid synthase Other names: FASN (gene name) click to see details on this item	[c] : accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + (20) hName: H+ Formula: H Charge: 1 click to see details on this item + (7) malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (14) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(7) co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + (8) coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (6) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + hdcaName: Hexadecanoate (n-C16:0) Formula: C16H31O2 Charge: -1 click to see details on this item + (14) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	fasn-1	Fatty acid biosynthesis
RCC0145Name: fatty acid synthetase (n-C14:0) Type: Regular Location: Cytosol KEGG ID: R05188 click to see details on this item	2.3.1.85Name: fatty-acid synthase Other names: FASN (gene name) click to see details on this item	[c] : accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + (17) hName: H+ Formula: H Charge: 1 click to see details on this item + (6) malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (12) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(6) co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + (7) coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + (5) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + (12) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + ttdcaName: tetradecanoate (n-C14:0) Formula: C14H27O2 Charge: -1 click to see details on this item	fasn-1	Fatty acid biosynthesis
RCC0071Name: branched-chain fatty acid synthase Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	2.3.1.85Name: fatty-acid synthase Other names: FASN (gene name) click to see details on this item	[c] : (11) hName: H+ Formula: H Charge: 1 click to see details on this item + ivcoaName: Isovaleryl-CoA Formula: C26H40N7O17P3S Charge: -4 click to see details on this item + (4) malcoaName: Malonyl-CoA Formula: C24H33N7O19P3S Charge: -5 click to see details on this item + (8) nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		(4) co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + (5) coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + fa13p0isoName: Fatty acid (C13:iso) Formula: C13H25O2 Charge: -1 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + (8) nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	fasn-1	Fatty acid biosynthesis

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