WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.6.3.1
Name .....................................................	:	NAD(P)H oxidase (H2O2-forming), etc.THOX2, ThOX, Dual oxidase, P138tox, Thyroid NADPH oxidase, Thyroid oxidase, Thyroid oxidase 2, NADPH oxidase, NAD(P)H:oxygen oxidoreductase, NAD(P)H oxidase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K13411DUOX THOX; dual oxidase [EC:1.6.3.1 1.11.1.-]
Genes .....................................................	:	bli-3, duox-2
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0175Name: Tropocollagen crosslinking by dual oxidase Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	1.6.3.1Name: NAD(P)H oxidase (H2O2-forming) Other names: THOX2, ThOX, dual oxidase, p138tox, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, NADPH oxidase, NAD(P)H:oxygen oxidoreductase, NAD(P)H oxidase click to see details on this item 1.11.1.7Name: peroxidase Other names: lactoperoxidase, guaiacol peroxidase, plant peroxidase, Japanese radish peroxidase, horseradish peroxidase (HRP), soybean peroxidase (SBP), extensin peroxidase, heme peroxidase, oxyperoxidase, protoheme peroxidase, pyrocatechol peroxidase, scopoletin peroxidase, Coprinus cinereus peroxidase, Arthromyces ramosus peroxidase click to see details on this item	[c] : (2) tropcollgtyrName: Tropocollagen L-tyrosine (to be cross-linked) Formula: XH Charge: 0 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		(2) tropcollgtyrXName: Tropocollagen L-tyrosine (cross-linked) Formula: X Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	bli-3	Collagen biosynthesis
RC07172Name: NADPH:oxygen oxidoreductase Type: Regular Location: Cytosol KEGG ID: R07172 click to see details on this item	1.6.3.1Name: NAD(P)H oxidase (H2O2-forming) Other names: THOX2, ThOX, dual oxidase, p138tox, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, NADPH oxidase, NAD(P)H:oxygen oxidoreductase, NAD(P)H oxidase click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	bli-3 \| duox-2	Miscellaneous

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