WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.2.1.88
Name .....................................................	:	L-glutamate gamma-semialdehyde dehydrogenase, etc.1-pyrroline-5-carboxylate dehydrogenase, Delta1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, Pyrroline-5-carboxylate dehydrogenase, Pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase, Delta1-pyrroline-5-carboxylic acid dehydrogenase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00294E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
Genes .....................................................	:	alh-6
Localization .....................................................	:	Mitochondria
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM00245Name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00245 click to see details on this item	1.2.1.88Name: L-glutamate gamma-semialdehyde dehydrogenase Other names: 1-pyrroline-5-carboxylate dehydrogenase, Delta1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase, Delta1-pyrroline-5-carboxylic acid dehydrogenase click to see details on this item	[m] : glu5saName: L-Glutamate 5-semialdehyde Formula: C5H9NO3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	alh-6	Arginine metabolism
RM05051Name: L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R05051 click to see details on this item	1.2.1.88Name: L-glutamate gamma-semialdehyde dehydrogenase Other names: 1-pyrroline-5-carboxylate dehydrogenase, Delta1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase, Delta1-pyrroline-5-carboxylic acid dehydrogenase click to see details on this item	[m] : 4hglusaName: L-4-Hydroxyglutamate semialdehyde Formula: C5H9NO4 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	alh-6	Proline metabolism

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