WormFlux: mechanistic analysis of C. elegans metabolism

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? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	7thf
Name .....................................................	:	heptaglutamyl folate (THF)
Model ID .....................................................	:	CC0005
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	Not available
Formula .....................................................	:	C49H57N13O24
Charge .....................................................	:	-8
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	7thf
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate cycle (m)

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RMC0024Name: Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 7thf) Type: Regular Location: Mitochondria KEGG ID: R04241;R00942 click to see details on this item	6.3.2.17Name: tetrahydrofolate synthase Other names: folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-gamma-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(gamma-glutamate) synthase, folylpolyglutamate synthetase, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) click to see details on this item	[m] : (2) atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + (2) glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + 5thfName: pentaglutamyl folate (THF) Formula: C39H45N11O18 Charge: -6 click to see details on this item		7thfName: heptaglutamyl folate (THF) Formula: C49H57N13O24 Charge: -8 click to see details on this item + (2) adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + (2) piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	F25B5.6	Folate cycle
DMN0046Name: polyglutamylated thf demand (cytosol) Type: Demand Location: Cytosol KEGG ID: NA click to see details on this item	Not applicable	7thfName: heptaglutamyl folate (THF) Formula: C49H57N13O24 Charge: -8 click to see details on this item[c]			Not applicable	Demand reactions
DMN0047Name: polyglutamylated thf demand (mitochondrial) Type: Demand Location: Mitochondria KEGG ID: NA click to see details on this item	Not applicable	7thfName: heptaglutamyl folate (THF) Formula: C49H57N13O24 Charge: -8 click to see details on this item[m]			Not applicable	Demand reactions
TCM0174Name: heptaglutamyl folate (THF) transport Type: Transport Location: Cytosol, Mitochondria KEGG ID: NA click to see details on this item	Not applicable	7thfName: heptaglutamyl folate (THF) Formula: C49H57N13O24 Charge: -8 click to see details on this item[m]		7thfName: heptaglutamyl folate (THF) Formula: C49H57N13O24 Charge: -8 click to see details on this item[c]	Not determined	Transport

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