WormFlux: mechanistic analysis of C. elegans metabolism

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? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	5fthf
Name .....................................................	:	5-Formyltetrahydrofolate, etc.Folinic acid, Leucovorin, L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
Model ID .....................................................	:	C03479
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C03479
Formula .....................................................	:	C20H21N7O7
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	5fthf
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Folate cycle (m)

iCEL1314

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Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM02300Name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) Type: Regular Location: Mitochondria KEGG ID: R02300 click to see details on this item	2.1.2.10Name: aminomethyltransferase Other names: S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming), T-protein, glycine synthase, tetrahydrofolate aminomethyltransferase, [protein]-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) click to see details on this item	[m] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + methfName: "5,10-Methenyltetrahydrofolate" Formula: C20H20N7O6 Charge: -1 click to see details on this item		5fthfName: 5-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	gcst-1	Folate cycle
RM02301Name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) Type: Regular Location: Mitochondria KEGG ID: R02301 click to see details on this item	6.3.3.2Name: 5-formyltetrahydrofolate cyclo-ligase Other names: 5,10-methenyltetrahydrofolate synthetase, formyltetrahydrofolic cyclodehydrase, 5-formyltetrahydrofolate cyclodehydrase click to see details on this item	[m] : 5fthfName: 5-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item + atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + methfName: "5,10-Methenyltetrahydrofolate" Formula: C20H20N7O6 Charge: -1 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	Y106G6E.4	Folate cycle
TCE0709Name: 5-Formyltetrahydrofolate and hydroxide ion transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	5fthfName: 5-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item[e] + oh1Name: hydroxide ion Formula: HO Charge: -1 click to see details on this item[c]		5fthfName: 5-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item[c] + oh1Name: hydroxide ion Formula: HO Charge: -1 click to see details on this item[e]	Not determined	Transport
EX03479Name: 5-Formyltetrahydrofolate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	5fthfName: 5-Formyltetrahydrofolate Formula: C20H21N7O7 Charge: -2 click to see details on this item[e]			Not applicable	Exchange with the environment

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