Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	ppa
Name .....................................................	:	Propionate (n-C3:0), etc.Propanoate, Propionate, Propanoic acid, Propionic acid
Model ID .....................................................	:	C00163
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00163
Formula .....................................................	:	C3H5O2
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	ppa
Other associations .....................................................	:	See reaction table below (6 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Propionate degradation (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RCC0022Name: Propionyladenylate:CoA propionyltransferase; ATP:propanoate adenylyltransferase Type: Regular Location: Cytosol KEGG ID: R00926;R01354 click to see details on this item	6.2.1.1Name: acetate---CoA ligase Other names: acetyl-CoA synthetase, acetyl activating enzyme, acetate thiokinase, acyl-activating enzyme, acetyl coenzyme A synthetase, acetic thiokinase, acetyl CoA ligase, acetyl CoA synthase, acetyl-coenzyme A synthase, short chain fatty acyl-CoA synthetase, short-chain acyl-coenzyme A synthetase, ACS click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item		ampName: AMP Formula: C10H12N5O7P Charge: -2 click to see details on this item + ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item + ppiName: Diphosphate Formula: HO7P2 Charge: -3 click to see details on this item	acs-19	Propionate degradation
RM00383Name: Acyl-CoA hydrolase Type: Regular Location: Mitochondria KEGG ID: R00383 click to see details on this item	3.1.2.18Name: ADP-dependent short-chain-acyl-CoA hydrolase Other names: short-chain acyl coenzyme A hydrolase, propionyl coenzyme A hydrolase, propionyl-CoA hydrolase, propionyl-CoA thioesterase, short-chain acyl-CoA hydrolase, short-chain acyl-CoA thioesterase click to see details on this item	[m] : ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Unknown	Propionate degradation
RC00383Name: Acyl-CoA hydrolase Type: Regular Location: Cytosol KEGG ID: R00383 click to see details on this item	3.1.2.18Name: ADP-dependent short-chain-acyl-CoA hydrolase Other names: short-chain acyl coenzyme A hydrolase, propionyl coenzyme A hydrolase, propionyl-CoA hydrolase, propionyl-CoA thioesterase, short-chain acyl-CoA hydrolase, short-chain acyl-CoA thioesterase click to see details on this item	[c] : ppcoaName: Propanoyl-CoA Formula: C24H36N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Unknown	Propionate degradation
TCM5034Name: propionate transfer between mitochondria and cytosol Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item[c]		ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item[m]	Not determined	Transport
TCE5035Name: propionate transport into and out of cytosol Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item[e]		ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item[c]	Not determined	Transport
EX00163Name: Propionate (n-C3:0) exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	ppaName: Propionate (n-C3:0) Formula: C3H5O2 Charge: -1 click to see details on this item[e]			Not applicable	Exchange with the environment

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