Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.5.1.20
Name .....................................................	:	Methylenetetrahydrofolate reductase [NAD(P)H], etc.Methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-CH2-H4folate reductase, Methylenetetrahydrofolate reductase (NADPH2), 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, Methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, 5,10-methylenetetrahydrofolate reductase, Methylenetetrahydrofolate reductase, N5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydropteroylglutamate reductase, N5,N10-methylenetetrahydrofolate reductase, Methylenetetrahydrofolic acid reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect), 5,10-methylenetetrahydrofolate reductase (FADH2), MetF, Methylenetetrahydrofolate reductase (NADPH), 5-methyltetrahydrofolate:NADP+ oxidoreductase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00297metF MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]
Genes .....................................................	:	mthf-1
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01224Name: 5-methyltetrahydrofolate:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01224 click to see details on this item	1.5.1.20Name: methylenetetrahydrofolate reductase [NAD(P)H] Other names: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-CH2-H4folate reductase, methylenetetrahydrofolate reductase (NADPH2), 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, 5,10-methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase, N5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydropteroylglutamate reductase, N5,N10-methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect), 5,10-methylenetetrahydrofolate reductase (FADH2), MetF, methylenetetrahydrofolate reductase (NADPH), 5-methyltetrahydrofolate:NADP+ oxidoreductase click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + mlthfName: "5,10-Methylenetetrahydrofolate" Formula: C20H21N7O6 Charge: -2 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	mthf-1	Folate cycle
RC07168Name: 5-methyltetrahydrofolate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R07168 click to see details on this item	1.5.1.20Name: methylenetetrahydrofolate reductase [NAD(P)H] Other names: methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-CH2-H4folate reductase, methylenetetrahydrofolate reductase (NADPH2), 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, 5,10-methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase, N5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydropteroylglutamate reductase, N5,N10-methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect), 5,10-methylenetetrahydrofolate reductase (FADH2), MetF, methylenetetrahydrofolate reductase (NADPH), 5-methyltetrahydrofolate:NADP+ oxidoreductase click to see details on this item	[c] : (2) hName: H+ Formula: H Charge: 1 click to see details on this item + mlthfName: "5,10-Methylenetetrahydrofolate" Formula: C20H21N7O6 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		5mthfName: 5-Methyltetrahydrofolate Formula: C20H24N7O6 Charge: -1 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item	mthf-1	Folate cycle

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