WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.5.1.2
Name .....................................................	:	Pyrroline-5-carboxylate reductase, etc.Proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00286E1.5.1.2 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Genes .....................................................	:	F55G1.9, M153.1
Localization .....................................................	:	Mitochondria
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01248Name: L-Proline:NAD+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R01248 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 1pyr5cName: 1-Pyrroline-5-carboxylate Formula: C5H6NO2 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item		nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + pro-LName: L-Proline Formula: C5H9NO2 Charge: 0 click to see details on this item	M153.1 \| F55G1.9	Proline metabolism
RM03291Name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03291 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	M153.1 \| F55G1.9	Proline metabolism
RM03293Name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R03293 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 4hpro-LTName: trans-4-Hydroxy-L-proline Formula: C5H9NO3 Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		1p3h5cName: L-1-Pyrroline-3-hydroxy-5-carboxylate Formula: C5H6NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	M153.1 \| F55G1.9	Proline metabolism
RM01251Name: L-Proline:NADP+ 5-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R01251 click to see details on this item	1.5.1.2Name: pyrroline-5-carboxylate reductase Other names: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase click to see details on this item	[m] : 1pyr5cName: 1-Pyrroline-5-carboxylate Formula: C5H6NO2 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + pro-LName: L-Proline Formula: C5H9NO2 Charge: 0 click to see details on this item	M153.1 \| F55G1.9	Arginine metabolism

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