Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	1.14.13.17
Name .....................................................	:	Cholesterol 7alpha-monooxygenase, etc.Cholesterol 7alpha-hydroxylase, CYP7A1
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	Not determined
Genes .....................................................	:	Not determined
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01463Name: Cholesterol,NADPH:oxygen oxidoreductase Type: Regular Location: Cytosol KEGG ID: R01463 click to see details on this item	1.14.13.17Name: cholesterol 7alpha-monooxygenase Other names: cholesterol 7alpha-hydroxylase, CYP7A1 click to see details on this item	[c] : chsterolName: Cholesterol Formula: C27H46O Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + xol7aName: 7 alpha-Hydroxycholesterol Formula: C27H46O2 Charge: 0 click to see details on this item	To be determined	Biosynthesis of bile acid-like molecules
RC07372Name: oxysterol 7alpha-hydroxylase (acting on 27-hydroxycholesterol) Type: Regular Location: Cytosol KEGG ID: R07372 click to see details on this item	1.14.13.100Name: 25/26-hydroxycholesterol 7alpha-hydroxylase Other names: 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, 27-hydroxycholesterol 7-monooxygenase, 27-hydroxycholesterol 7alpha-hydroxylase, cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating), 25-hydroxycholesterol 7alpha-hydroxylase click to see details on this item 1.14.13.17Name: cholesterol 7alpha-monooxygenase Other names: cholesterol 7alpha-hydroxylase, CYP7A1 click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + xol27ohName: 27-Hydroxycholesterol Formula: C27H46O2 Charge: 0 click to see details on this item		h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item + xoltri27Name: "7-alpha,27-Dihydroxycholesterol" Formula: C27H46O3 Charge: 0 click to see details on this item	To be determined	Biosynthesis of bile acid-like molecules

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