WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	5hoxindoa
Name .....................................................	:	5-Hydroxyindoleacetate
Model ID .....................................................	:	C05635
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C05635
Formula .....................................................	:	C10H8NO3
Charge .....................................................	:	-1
Localization .....................................................	:	Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	5hoxindoa
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Tryptophan degradation (c,e)

iCEL1314

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Enzyme

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Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC04903Name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R04903 click to see details on this item	1.2.1.3Name: aldehyde dehydrogenase (NAD+) Other names: CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, aldehyde dehydrogenase (NAD) click to see details on this item	[c] : 5hoxindactName: 5-Hydroxyindoleacetaldehyde Formula: C10H9NO2 Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		5hoxindoaName: 5-Hydroxyindoleacetate Formula: C10H8NO3 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	(alh-2 \| alh-4) \| (alh-11 \| alh-12)	Tryptophan degradation
TCE7572Name: 5-Hydroxyindoleacetate transport Type: Transport Location: Extracellular, Cytosol KEGG ID: NA click to see details on this item	Not applicable	5hoxindoaName: 5-Hydroxyindoleacetate Formula: C10H8NO3 Charge: -1 click to see details on this item[c]		5hoxindoaName: 5-Hydroxyindoleacetate Formula: C10H8NO3 Charge: -1 click to see details on this item[e]	Not determined	Transport
EX05635Name: 5-Hydroxyindoleacetate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	5hoxindoaName: 5-Hydroxyindoleacetate Formula: C10H8NO3 Charge: -1 click to see details on this item[e]			Not applicable	Exchange with the environment

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