Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Metabolite Overview

Abbreviation .....................................................	:	hx2coa
Name .....................................................	:	trans-Hex-2-enoyl-CoA, etc.(2E)-Hexenoyl-CoA
Model ID .....................................................	:	C05271
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C05271
Formula .....................................................	:	C27H40N7O17P3S
Charge .....................................................	:	-4
Localization .....................................................	:	Mitochondria
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	hx2coa
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Mitochondrial fatty acid degradation (m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM04749Name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Type: Regular Location: Mitochondria KEGG ID: R04749 click to see details on this item	4.2.1.17Name: enoyl-CoA hydratase Other names: enoyl hydrase, unsaturated acyl-CoA hydratase, beta-hydroxyacyl-CoA dehydrase, beta-hydroxyacid dehydrase, hydratase, enoyl coenzyme A, acyl coenzyme A hydrase, crotonase, crotonyl hydrase, 2-octenoyl coenzyme A hydrase, enoyl coenzyme A hydratase, 2-enoyl-CoA hydratase, short-chain enoyl-CoA hydratase, ECH, trans-2-enoyl-CoA hydratase, enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), short chain enoyl coenzyme A hydratase, D-3-hydroxyacyl-CoA dehydratase, enol-CoA hydratase click to see details on this item	[m] : 3hhcoaName: (S)-3-Hydroxyhexanoyl-CoA Formula: C27H42N7O18P3S Charge: -4 click to see details on this item		h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + hx2coaName: trans-Hex-2-enoyl-CoA Formula: C27H40N7O17P3S Charge: -4 click to see details on this item	(ech-6 | ech-7) | (ech-1.2 | ech-1.1) | ech-3	Mitochondrial fatty acid degradation
RM06985Name: trans-Hex-2-enoyl-CoA reductase Type: Regular Location: Mitochondria KEGG ID: R06985 click to see details on this item	1.3.1.38Name: trans-2-enoyl-CoA reductase (NADPH) Other names: NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, trans-2-enoyl-CoA reductase (NADPH2) click to see details on this item	[m] : hName: H+ Formula: H Charge: 1 click to see details on this item + hx2coaName: trans-Hex-2-enoyl-CoA Formula: C27H40N7O17P3S Charge: -4 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		hxcoaName: Hexanoyl-CoA (n-C6:0CoA) Formula: C27H42N7O17P3S Charge: -4 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	mecr-1 | Y48A6B.9	Mitochondrial fatty acid degradation
RM04751Name: Hexanoyl-CoA:(acceptor) 2,3-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R04751 click to see details on this item	1.3.8.7Name: medium-chain acyl-CoA dehydrogenase Other names: fatty acyl coenzyme A dehydrogenase (ambiguous), acyl coenzyme A dehydrogenase (ambiguous), acyl dehydrogenase (ambiguous), fatty-acyl-CoA dehydrogenase (ambiguous), acyl CoA dehydrogenase (ambiguous), general acyl CoA dehydrogenase (ambiguous), medium-chain acyl-coenzyme A dehydrogenase, acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous), ACADM (gene name). click to see details on this item 1.3.8.1Name: short-chain acyl-CoA dehydrogenase Other names: butyryl-CoA dehydrogenase, butanoyl-CoA dehydrogenase, butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, butanoyl-CoA:(acceptor) 2,3-oxidoreductase, ACADS (gene name). click to see details on this item	[m] : etfoxName: Electron transfer flavoprotein oxidized Formula: R Charge: 0 click to see details on this item + hxcoaName: Hexanoyl-CoA (n-C6:0CoA) Formula: C27H42N7O17P3S Charge: -4 click to see details on this item		etfrdName: Electron transfer flavoprotein reduced Formula: RH2 Charge: 0 click to see details on this item + hx2coaName: trans-Hex-2-enoyl-CoA Formula: C27H40N7O17P3S Charge: -4 click to see details on this item	(acdh-7 | acdh-8 | acdh-10) | (acdh-1 | acdh-2)	Mitochondrial fatty acid degradation

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