WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	am6sa
Name .....................................................	:	2-Aminomuconate 6-semialdehyde, etc.2-Aminomuconate semialdehyde
Model ID .....................................................	:	C03824
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C03824
Formula .....................................................	:	C6H7NO3
Charge .....................................................	:	0
Localization .....................................................	:	Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	am6sa
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Tryptophan degradation (c)

iCEL1314

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Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC04323Name: 2-Amino-3-carboxymuconate semialdehyde carboxy-lyase Type: Regular Location: Cytosol KEGG ID: R04323 click to see details on this item	4.1.1.45Name: aminocarboxymuconate-semialdehyde decarboxylase Other names: picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase click to see details on this item	[c] : cmusaName: 2-Amino-3-carboxymuconate semialdehyde Formula: C7H6NO5 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		am6saName: 2-Aminomuconate 6-semialdehyde Formula: C6H7NO3 Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	acsd-1	Tryptophan degradation
RC03889Name: 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase Type: Regular Location: Cytosol KEGG ID: R03889 click to see details on this item	1.2.1.32Name: aminomuconate-semialdehyde dehydrogenase Other names: 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase click to see details on this item	[c] : am6saName: 2-Aminomuconate 6-semialdehyde Formula: C6H7NO3 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		amucoName: 2-Aminomuconate Formula: C6H6NO4 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	To be determined	Tryptophan degradation

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